Document Detail

A role of renal K+-stimulated phosphatase activity on elevation of urinary sodium excretion in fluoride-treated rats.
MedLine Citation:
PMID:  6306869     Owner:  NLM     Status:  MEDLINE    
Fluoride administered to nonfasted rats caused an elevation of urinary sodium excretion but not an increased urinary potassium excretion as previously observed by one of us in fasted rats. This elevated urinary sodium excretion was associated with decreased renal K+-stimulated phosphatase activity. The decreased phosphatase activity was reversed by treatment with aldosterone, but not by treatment with prednisolone.
Y Suketa; M Kuwahara; K Sahashi; N Suzuki; Y Akiyama
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Toxicology and applied pharmacology     Volume:  69     ISSN:  0041-008X     ISO Abbreviation:  Toxicol. Appl. Pharmacol.     Publication Date:  1983 Jun 
Date Detail:
Created Date:  1983-08-26     Completed Date:  1983-08-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0416575     Medline TA:  Toxicol Appl Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  225-33     Citation Subset:  IM    
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MeSH Terms
Aldosterone / pharmacology
Fluorides / pharmacology*
Kidney / drug effects,  enzymology*
Magnesium / pharmacology
Microsomes / enzymology
Natriuresis / drug effects*
Phosphoric Monoester Hydrolases / antagonists & inhibitors*
Potassium / pharmacology,  urine
Prednisolone / pharmacology
Rats, Inbred Strains
Sodium Fluoride / pharmacology
Reg. No./Substance:
0/Fluorides; 50-24-8/Prednisolone; 52-39-1/Aldosterone; 7439-95-4/Magnesium; 7440-09-7/Potassium; 7681-49-4/Sodium Fluoride; EC 3.1.3.-/Phosphoric Monoester Hydrolases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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