Document Detail

The role of reducing intakes of saturated fat in the prevention of cardiovascular disease: where does the evidence stand in 2010?
MedLine Citation:
PMID:  21270379     Owner:  NLM     Status:  MEDLINE    
Current dietary recommendations advise reducing the intake of saturated fatty acids (SFAs) to reduce coronary heart disease (CHD) risk, but recent findings question the role of SFAs. This expert panel reviewed the evidence and reached the following conclusions: the evidence from epidemiologic, clinical, and mechanistic studies is consistent in finding that the risk of CHD is reduced when SFAs are replaced with polyunsaturated fatty acids (PUFAs). In populations who consume a Western diet, the replacement of 1% of energy from SFAs with PUFAs lowers LDL cholesterol and is likely to produce a reduction in CHD incidence of ≥2-3%. No clear benefit of substituting carbohydrates for SFAs has been shown, although there might be a benefit if the carbohydrate is unrefined and has a low glycemic index. Insufficient evidence exists to judge the effect on CHD risk of replacing SFAs with MUFAs. No clear association between SFA intake relative to refined carbohydrates and the risk of insulin resistance and diabetes has been shown. The effect of diet on a single biomarker is insufficient evidence to assess CHD risk. The combination of multiple biomarkers and the use of clinical endpoints could help substantiate the effects on CHD. Furthermore, the effect of particular foods on CHD cannot be predicted solely by their content of total SFAs because individual SFAs may have different cardiovascular effects and major SFA food sources contain other constituents that could influence CHD risk. Research is needed to clarify the role of SFAs compared with specific forms of carbohydrates in CHD risk and to compare specific foods with appropriate alternatives.
Arne Astrup; Jørn Dyerberg; Peter Elwood; Kjeld Hermansen; Frank B Hu; Marianne Uhre Jakobsen; Frans J Kok; Ronald M Krauss; Jean Michel Lecerf; Philippe LeGrand; Paul Nestel; Ulf Risérus; Tom Sanders; Andrew Sinclair; Steen Stender; Tine Tholstrup; Walter C Willett
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Publication Detail:
Type:  Consensus Development Conference; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2011-01-26
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  93     ISSN:  1938-3207     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-03-22     Completed Date:  2011-05-26     Revised Date:  2014-09-08    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  684-8     Citation Subset:  AIM; IM    
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MeSH Terms
Cholesterol / blood
Coronary Disease / blood,  etiology,  prevention & control*
Diabetes Mellitus
Dietary Carbohydrates / pharmacology
Dietary Fats / administration & dosage*
Fatty Acids / adverse effects*
Fatty Acids, Unsaturated / administration & dosage*
Insulin Resistance
Grant Support
Reg. No./Substance:
0/Dietary Carbohydrates; 0/Dietary Fats; 0/Fatty Acids; 0/Fatty Acids, Unsaturated; 97C5T2UQ7J/Cholesterol

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