Document Detail

The role of recombinant human tissue-type plasminogen activator in the treatment of acute pulmonary thromboembolism.
MedLine Citation:
PMID:  1450496     Owner:  NLM     Status:  MEDLINE    
The effect of intravenous recombinant human tissue-type plasminogen activator (tPA) on arterial blood gases was compared with the effect of heparin treatment in acute pulmonary thromboembolism. Fifteen patients received heparin alone (group A), 5 cases were treated with 7.7 x 10(6) I.U. of tPA (group B) and 10 cases with 15 x 10(6) I.U. of tPA (group C) combined with heparin treatment. Arterial oxygen tension before treatment was not significantly different among the three groups. PaO2 was dramatically improved on the 1st day in group C. By the 7th day, PaO2 of group B had improved to the level of group C. However, the PaO2 of group A on the 7th day was not significantly different compared to the pre-treatment value. In group C, post-treatment perfusion lung scintigrams were improved compared to the pre-treatment images, but this was not the case in group B. Treatment with tPA is more effective for acute pulmonary thromboembolism than heparin alone and a high dose of tPA (15 x 10(6) I.U.) leads to rapid improvement in arterial blood gases and lung perfusion images.
F Yamasawa; Y Okada; K Asano; M Mori; H Fujita; N Hasegawa; T Aoki; A Ishizaka; M Kanazawa; T Kawashiro
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Internal medicine (Tokyo, Japan)     Volume:  31     ISSN:  0918-2918     ISO Abbreviation:  Intern. Med.     Publication Date:  1992 Jul 
Date Detail:
Created Date:  1993-01-07     Completed Date:  1993-01-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9204241     Medline TA:  Intern Med     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  885-8     Citation Subset:  IM    
Department of Medicine, School of Medicine, Keio University, Tokyo, Japan.
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MeSH Terms
Acute Disease
Drug Therapy, Combination
Fibrin Fibrinogen Degradation Products / analysis
Fibrinogen / analysis
Heparin / therapeutic use
Oxygen / blood
Partial Pressure
Pulmonary Embolism / blood,  drug therapy*,  radionuclide imaging
Recombinant Fusion Proteins / therapeutic use
Tissue Plasminogen Activator / therapeutic use*
Reg. No./Substance:
0/Fibrin Fibrinogen Degradation Products; 0/Recombinant Fusion Proteins; 7782-44-7/Oxygen; 9001-32-5/Fibrinogen; 9005-49-6/Heparin; EC Plasminogen Activator

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