Document Detail


The role of the read through variant of acetylcholinesterase in anxiogenic effects of predator stress in mice.
MedLine Citation:
PMID:  18243359     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study examined the role of the read through variant of acetylcholinesterase (AChE-R) in lasting changes in murine affective behavior produced by a brief predator stress. AChE-R is elevated by stress in limbic cholinergic circuits implicated in anxiogenic effects of predator stress. The expression of AChE-R was blocked with a systemically administered central acting antisense oligonucleotide for AChE-R (EN101). EN101 was injected at multiple points prior to and after a predator stress in male C57 mice. Seven days after the last injection, behavior was tested. Predator stress caused a significant increase in startle amplitude, which EN101 blocked. This effect was specific to EN101, as the negative control inactive form of EN101, INVEN101 was without effect on stress effects on startle. Neither EN101 nor INVEN101 altered the anxiogenic effects of predator stress on behavior in the elevated plus maze, and both drugs partially reduced stress suppression of time active in the hole board. In the light dark box test, INVEN101 exhibited a weak block of stress effects on behavior for reasons which are unclear. Taken together, findings support the view that multiple neural systems are responsible for the different changes in behavior produced by predator stress. Present findings also suggest a role for AChE-R in specific anxiogenic (hyperarousal) effects following predator stress. Since AChE-R manipulations took place starting 23 h prior to predator stress and continued 48 h after predator stress, further research is necessary to determine the role of AChE-R in initiation and/or consolidation of hyperarousal effects of predator stress.
Authors:
Robert Adamec; David Head; Hermona Soreq; Jacqueline Blundell
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-01-05
Journal Detail:
Title:  Behavioural brain research     Volume:  189     ISSN:  0166-4328     ISO Abbreviation:  Behav. Brain Res.     Publication Date:  2008 May 
Date Detail:
Created Date:  2008-03-18     Completed Date:  2008-07-01     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8004872     Medline TA:  Behav Brain Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  180-90     Citation Subset:  IM    
Affiliation:
Department of Psychology, Memorial University, 232 Elizabeth Avenue, St. John's, NF, A1B 3X9 Canada. radamec@mun.ca
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MeSH Terms
Descriptor/Qualifier:
Acetylcholinesterase / genetics,  metabolism*
Affect
Analysis of Variance
Animals
Anxiety / complications,  genetics*,  metabolism
Arousal / genetics,  physiology*
Cats
Exploratory Behavior / physiology
Gene Expression Regulation / physiology
Genetic Variation
Male
Mice
Mice, Inbred C57BL
Neural Pathways / metabolism*
Oligodeoxyribonucleotides / metabolism
Predatory Behavior
Random Allocation
Startle Reaction / genetics,  physiology
Stress, Psychological / complications,  metabolism*
Chemical
Reg. No./Substance:
0/EN101; 0/Oligodeoxyribonucleotides; EC 3.1.1.7/Acetylcholinesterase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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