Document Detail

The role of pulmonary CO2 flow in the control of the phase I ventilatory response to exercise in humans.
MedLine Citation:
PMID:  8549569     Owner:  NLM     Status:  MEDLINE    
To gain an insight into the origin of the phase I ventilatory response to exercise (ph I) in humans, pulmonary ventilation (VE) and end-tidal partial pressures of oxygen and carbon dioxide (PETO2 and PETCO2, respectively) were measured breath-by-breath in six male subjects during constant-intensity exercise on the cycle ergometer at 50, 100 and 150 W, with eupnoeic normocapnia (N) or hyperpnoeic hypocapnia (H) established prior to the exercise test. Cardiac output (Qc) was also determined beat-by-beat by impedance cardiography on eight subjects during moderate exercise (50 W), and the CO2 flow to the lungs (Qc.Cv-CO2 where Cv-CO2 is concentration of CO2 in mixed veneous blood) was estimated with a time resolution of one breathing cycle. In N, the initial abrupt increase of VE during ph I (delta VE approximately 18 1.min-1 above rest) was followed by a transient fall. When PETCO2 started to increase (and PETO2 decreased) VE increased again (phase II ventilatory response, ph II). In H, during ph I delta VE was similar to that of N. By contrast, during ph II delta VE kept gradually decreasing and started to increase only when PETCO2 had returned to approximately 40 mmHg (5.3 kPa). Thus, as a result of the prevailing initial conditions (N or H) a temporal shift of the time-course of VE during ph II became apparent. No correlation was found between CO2 flow to the lungs and VE during ph I. These results are interpreted as suggesting that an increased CO2 flow to the lungs does not constitute an important factor for the initial hyperventilatory response to exercise. They are rather compatible with a neural origin of ph I, and would support the "neurohumoral" theory of ventilatory control during exercise.
P Cerretelli; B Grassi; L Xi; F Schena; C Marconi; M Meyer; G Ferretti
Related Documents :
7235359 - The influence of active gas exchange on the slope of phase iii at rest and after exercise.
16159059 - Ventilation patterns in patients with severe traumatic brain injury following paramedic...
9159979 - Repeated exposure to interoceptive cues: does habituation of fear occur in panic disord...
6439709 - Changes in the vi-vco2 relationship during exercise in goats: role of carotid bodies.
23013489 - Can exercise ameliorate treatment toxicity during the initial phase of testosterone dep...
3924099 - Evidence for hco3- conductance pathways in nutrient membrane of bullfrog antrum.
3748609 - The seasonal occurrence of trilocularia acanthiaevulgaris (cestoda: tetraphyllidea) fro...
16246649 - Functional capacity and cardiovascular assessment: submaximal exercise testing and hidd...
14641039 - Experiment and computer-aided simulation: complementary tools to understand exercise me...
Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of applied physiology and occupational physiology     Volume:  71     ISSN:  0301-5548     ISO Abbreviation:  Eur J Appl Physiol Occup Physiol     Publication Date:  1995  
Date Detail:
Created Date:  1996-02-22     Completed Date:  1996-02-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0410266     Medline TA:  Eur J Appl Physiol Occup Physiol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  287-94     Citation Subset:  IM    
Department of Physiology, CMU, Université de Genéve, Switzerland.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Blood Gas Analysis
Carbon Dioxide / blood,  physiology*
Cardiography, Impedance
Exercise / physiology*
Hydrogen-Ion Concentration
Lung / physiology*
Oxygen / blood
Oxygen Consumption / physiology
Respiratory Mechanics / physiology*
Reg. No./Substance:
124-38-9/Carbon Dioxide; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Biomarkers and pediatric environmental health.
Next Document:  The comparison of peak oxygen uptake between swim-bench exercise and arm stroke.