Document Detail

The role of proton pump inhibitors in the treatment of heartburn during pregnancy.
MedLine Citation:
PMID:  15679877     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To review the problem of heartburn in gravid women, discuss the present treatment options, and examine the use of proton pump inhibitors (PPIs) as one of the treatment options for moderate to severe heartburn. DATA SOURCES: Extensive review of worldwide scientific literature on the use and safety of PPIs during pregnancy and heartburn during pregnancy. CONCLUSIONS: Preliminary information indicates that use of PPIs during pregnancy is safe for both the fetus and the woman and that obstetrical practitioners are using them more frequently. Randomized controlled trials are needed to examine the efficacy of PPIs to treat heartburn during pregnancy, especially as they are compared to histamine(2) receptor antagonists. IMPLICATIONS FOR PRACTICE: Heartburn during pregnancy is at risk for being undertreated, given that delivery is the cure. As PPIs are more widely used by women, questions will arise regarding their use in the first trimester as well as throughout pregnancy. This article brings nurse practitioners up to date on the safety of PPIs through the literature review and suggests various treatment options that can be discussed with the patient.
Lesliea Christopher
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of the American Academy of Nurse Practitioners     Volume:  17     ISSN:  1041-2972     ISO Abbreviation:  J Am Acad Nurse Pract     Publication Date:  2005 Jan 
Date Detail:
Created Date:  2005-01-31     Completed Date:  2005-06-28     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8916634     Medline TA:  J Am Acad Nurse Pract     Country:  United States    
Other Details:
Languages:  eng     Pagination:  4-8     Citation Subset:  N    
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MeSH Terms
Anti-Ulcer Agents / therapeutic use*
Heartburn / complications,  drug therapy*
Pregnancy Complications / drug therapy*
Proton Pumps / antagonists & inhibitors*
Treatment Outcome
Reg. No./Substance:
0/Anti-Ulcer Agents; 0/Proton Pumps

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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