| The role of proteomics in the diagnosis of chorioamnionitis and early-onset neonatal sepsis. | |
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MedLine Citation:
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PMID: 20569812 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Intrauterine infection is a unique pathologic process that raises the risk for early-onset neonatal sepsis (EONS). By acting synergistically with prematurity, EONS increases the risk for adverse neonatal outcomes, including intraventricular hemorrhage and cerebral palsy. Although several pathways for the pathogenesis of fetal damage have been proposed, the basic molecular mechanisms that modulate these events remain incompletely understood. Discovery of clinically and biologically relevant biomarkers able to reveal key pathogenic pathways and predict pregnancies at risk for antenatal fetal damage is a priority. Proteomics provides a unique opportunity to fill this gap. |
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Authors:
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Irina A Buhimschi; Catalin S Buhimschi |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Clinics in perinatology Volume: 37 ISSN: 1557-9840 ISO Abbreviation: Clin Perinatol Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-06-23 Completed Date: 2010-10-14 Revised Date: 2011-09-26 |
Medline Journal Info:
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Nlm Unique ID: 7501306 Medline TA: Clin Perinatol Country: United States |
Other Details:
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Languages: eng Pagination: 355-74 Citation Subset: IM |
Affiliation:
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Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, 333 Cedar Street, LLCI 804, New Haven, CT 06520, USA. irina.buhimschi@yale.edu <irina.buhimschi@yale.edu> |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Biological Markers
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analysis Chorioamnionitis / diagnosis*, immunology, microbiology Defensins / immunology Diagnosis, Differential Female Glycosylation End Products, Advanced / immunology Humans Immunity, Innate Infant, Newborn Pregnancy Pregnancy Complications, Infectious / diagnosis*, immunology, microbiology Proteomics / methods* Risk Factors Sepsis / diagnosis*, immunology, microbiology Signal Transduction |
| Grant Support | |
ID/Acronym/Agency:
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R01 HD 047321/HD/NICHD NIH HHS; R01 HD047321-04/HD/NICHD NIH HHS; R01 HD047321-05/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Defensins; 0/Glycosylation End Products, Advanced |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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