Document Detail


The role of proteomics in the diagnosis of chorioamnionitis and early-onset neonatal sepsis.
MedLine Citation:
PMID:  20569812     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Intrauterine infection is a unique pathologic process that raises the risk for early-onset neonatal sepsis (EONS). By acting synergistically with prematurity, EONS increases the risk for adverse neonatal outcomes, including intraventricular hemorrhage and cerebral palsy. Although several pathways for the pathogenesis of fetal damage have been proposed, the basic molecular mechanisms that modulate these events remain incompletely understood. Discovery of clinically and biologically relevant biomarkers able to reveal key pathogenic pathways and predict pregnancies at risk for antenatal fetal damage is a priority. Proteomics provides a unique opportunity to fill this gap.
Authors:
Irina A Buhimschi; Catalin S Buhimschi
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Clinics in perinatology     Volume:  37     ISSN:  1557-9840     ISO Abbreviation:  Clin Perinatol     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-06-23     Completed Date:  2010-10-14     Revised Date:  2014-09-12    
Medline Journal Info:
Nlm Unique ID:  7501306     Medline TA:  Clin Perinatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  355-74     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Biological Markers / analysis
Chorioamnionitis / diagnosis*,  immunology,  microbiology
Defensins / immunology
Diagnosis, Differential
Female
Glycosylation End Products, Advanced / immunology
Humans
Immunity, Innate
Infant, Newborn
Pregnancy
Pregnancy Complications, Infectious / diagnosis*,  immunology,  microbiology
Proteomics / methods*
Risk Factors
Sepsis / diagnosis*,  immunology,  microbiology
Signal Transduction
Grant Support
ID/Acronym/Agency:
R01 HD 047321/HD/NICHD NIH HHS; R01 HD047321/HD/NICHD NIH HHS; R01 HD047321-04/HD/NICHD NIH HHS; R01 HD047321-05/HD/NICHD NIH HHS; R01 HD062007/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Defensins; 0/Glycosylation End Products, Advanced
Comments/Corrections

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