Document Detail


A role of protein degradation in memory consolidation after initial learning and extinction learning in the honeybee (Apis mellifera).
MedLine Citation:
PMID:  22988289     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Protein degradation is known to affect memory formation after extinction learning. We demonstrate here that an inhibitor of protein degradation, MG132, interferes with memory formation after extinction learning in a classical appetitive conditioning paradigm. In addition, we find an enhancement of memory formation when the same inhibitor is applied after initial learning. This result supports the idea that MG132 targets an ongoing consolidation process. Furthermore, we demonstrate that the sensitivity of memory formation after initial learning and extinction learning to MG132 depends in the same way on the number of CS-US trials and the intertrial interval applied during initial learning. This supports the idea that the learning parameters during acquisition are critical for memory formation after extinction and that protein degradation in both learning processes might be functionally linked.
Authors:
Johannes Felsenberg; Vincent Dombrowski; Dorothea Eisenhardt
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Publication Detail:
Type:  Journal Article     Date:  2012-09-17
Journal Detail:
Title:  Learning & memory (Cold Spring Harbor, N.Y.)     Volume:  19     ISSN:  1549-5485     ISO Abbreviation:  Learn. Mem.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-09-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9435678     Medline TA:  Learn Mem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  470-7     Citation Subset:  IM    
Affiliation:
FB Biologie, Pharmazie, Chemie, Institut für Biologie, Neurobiologie, Freie Universität Berlin, 14195 Berlin, Germany.
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