Document Detail

The role of prostaglandins in hepatic resection.
MedLine Citation:
PMID:  8171069     Owner:  NLM     Status:  MEDLINE    
The role of prostaglandins (PGs) and the efficacy of PGE1 were investigated in hepatic resection. Patients who underwent hepatic resection were randomly assigned to two groups consisting of a control (n = 5) and a PGE1 treatment group (n = 6). Then the amount of 6-keto PF1 alpha, thromboxane B2 and (TXB2) and PGE2 were serially measured both before and after hepatic resection. Regarding changes in the PGs, a remarkable increase in TXB2 during hepatectomy was demonstrated in both groups. In the control group, both 6-keto PF1 alpha and PGE2 showed only a slight increase both during and after the operation. Regarding the efficacy of PGE1 on liver damage, no significant difference in postoperative liver function was found, however the lipoperoxide level at postoperative day 3 in the PGE1 treatment group (1.9 +/- 0.4 nmol/ml) was significantly lower than that in the control (2.6 +/- 0.5 nmol/ml: P < 0.05). Judging from the remarkable increase of TXB2, a stable metabolite of TXA2 during hepatectomy, it may be suggested that TXA2 plays an important role in the development of liver damage during hepatic resection.
M Shimada; T Matsumata; A Taketomi; K Shirabe; K Yamamoto; K Sugimachi
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Prostaglandins, leukotrienes, and essential fatty acids     Volume:  50     ISSN:  0952-3278     ISO Abbreviation:  Prostaglandins Leukot. Essent. Fatty Acids     Publication Date:  1994 Feb 
Date Detail:
Created Date:  1994-06-02     Completed Date:  1994-06-02     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8802730     Medline TA:  Prostaglandins Leukot Essent Fatty Acids     Country:  SCOTLAND    
Other Details:
Languages:  eng     Pagination:  65-8     Citation Subset:  IM    
Second Department of Surgery, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
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MeSH Terms
6-Ketoprostaglandin F1 alpha / metabolism
Alprostadil / metabolism,  pharmacology*
Dinoprostone / metabolism
Lipid Peroxides / metabolism
Liver / drug effects*,  metabolism*,  surgery
Liver Function Tests
Middle Aged
Thromboxane A2 / metabolism
Thromboxane B2 / metabolism
Reg. No./Substance:
0/Lipid Peroxides; 363-24-6/Dinoprostone; 54397-85-2/Thromboxane B2; 57576-52-0/Thromboxane A2; 58962-34-8/6-Ketoprostaglandin F1 alpha; 745-65-3/Alprostadil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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