Document Detail

The role of prostaglandin F2 alpha in byssinosis.
MedLine Citation:
PMID:  7415965     Owner:  NLM     Status:  MEDLINE    
Female guinea pigs were perfused via the pulmonary artery with Tyrode's solution containing 0, 10(-6), 10(-5), or 10(-4) g/mL of lyophilized aqueous extracts of cotton dust. The perfusate was collected via the pulmonary vein and analyzed for prostaglandin F2 alpha, its metabolite 15-keto-13, 14-dihydro-prostaglandin F2 alpha and histamine. The histamine content of the pulmonary parenchyma was also analyzed. Prostaglandin F2 alpha, its metabolite, and the percentage of total histamine released increased in a dose related fashion and were significantly higher in the perfusate of the animals which had received the two highest doses than that of the controls. Since prostaglandin F2 alpha can increase airway resistance and bronchial smooth muscle contraction and decrease pulmonary tidal volume, its liberation into the respiratory system could play a role, along with histamine, in the acute bronchial constriction that follows the inhalation of cotton, flax, or hemp dust.
M H Elissalde; G A Greenblatt; R L Ziprin
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  American Industrial Hygiene Association journal     Volume:  41     ISSN:  0002-8894     ISO Abbreviation:  Am Ind Hyg Assoc J     Publication Date:  1980 May 
Date Detail:
Created Date:  1980-11-20     Completed Date:  1980-11-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0371160     Medline TA:  Am Ind Hyg Assoc J     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  382-4     Citation Subset:  IM    
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MeSH Terms
Byssinosis / metabolism*
Constriction, Pathologic
Guinea Pigs
Histamine / metabolism
Lung / drug effects,  metabolism*
Prostaglandins F / metabolism*
Stimulation, Chemical
Reg. No./Substance:
0/Prostaglandins F; 51-45-6/Histamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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