Document Detail

The role of prostaglandin E, cyclic AMP, and cyclic GMP in the proliferation of guinea-pig ear skin stimulated by topical application of vitamin A acid.
MedLine Citation:
PMID:  181494     Owner:  NLM     Status:  MEDLINE    
Daily treatment of guinea-pig ear skin with topical 0.5% retinoic acid in acetone produced erythematous scaly dermatitis. Histologic sections revealed bandlike thickening of the epidermis on days 2 to 4, psoriasiform acanthosis, papillomatosis and increased mitotic activity on days 5 to 6. Also seen were dilatation of the upper dermal blood vessels and a fibroblastic, histiocytic reaction in the dermis. Prostaglandin E, cyclic AMP, and cyclic GMP levels were increased in the treated skin and thymidine incorporation was enhanced. Cyclic AMP and GMP levels peaked on day 5 simultaneous with maximal epidermal hyperplasia, increased mitotic activity and dermal reaction. Tritiated thymidine uptake peaked on days 4 and 5, and prostaglandin E levels continued to increase up to day 6. Cyclic AMP phosphodiesterase activity of treated skin on day 5 did not appear to be significantly different from control.
K Aso; I Rabinowitz; E M Farber
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of investigative dermatology     Volume:  67     ISSN:  0022-202X     ISO Abbreviation:  J. Invest. Dermatol.     Publication Date:  1976 Aug 
Date Detail:
Created Date:  1976-10-02     Completed Date:  1976-10-02     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0426720     Medline TA:  J Invest Dermatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  231-4     Citation Subset:  AIM; IM    
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MeSH Terms
3',5'-Cyclic-AMP Phosphodiesterases / metabolism
Administration, Topical
Cell Division
Cyclic AMP / physiology*
Cyclic GMP / physiology*
Disease Models, Animal
Erythema / chemically induced
Guinea Pigs
Models, Biological
Prostaglandins E / physiology*
Psoriasis / chemically induced,  physiopathology*
Skin / drug effects*
Skin Physiological Phenomena
Thymidine / metabolism
Tretinoin / administration & dosage,  pharmacology*
Vitamin A / analogs & derivatives*
Reg. No./Substance:
0/Prostaglandins E; 11103-57-4/Vitamin A; 302-79-4/Tretinoin; 50-89-5/Thymidine; 60-92-4/Cyclic AMP; 7665-99-8/Cyclic GMP; EC',5'-Cyclic-AMP Phosphodiesterases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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