| A role for prostacyclin (PGi2) in excessive menstrual bleeding. | |
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MedLine Citation:
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PMID: 6111633 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The synthesis of prostanoids from arachidonic acid incubated with endometrium alone or together with myometrium was studied in women with excessive menstrual blood-loss (range 57--186 ml, median 86 ml). Production of prostaglandins F2 alpha, E2, and D2 was similar to that observed for the endometrium of women with normal periods (range 5--50 ml; median 11 ml). However, the endometrium from women with excessive menstrual blood-loss was more effective than endometrium from women with normal menstrual blood-loss at enhancing the production by a control preparation of myometrium of 6-oxo-prostaglandin F1 alpha, the stable metabolite of prostacyclin. The ability of the uterus to generate prostacyclin, a prostaglandin known to inhibit platelet aggregation and stimulate vasodilatation, may influence the degree and duration of menstrual bleeding. |
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Authors:
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S K Smith; M H Abel; R W Kelly; D T Baird |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Lancet Volume: 1 ISSN: 0140-6736 ISO Abbreviation: Lancet Publication Date: 1981 Mar |
Date Detail:
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Created Date: 1981-06-13 Completed Date: 1981-06-13 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 2985213R Medline TA: Lancet Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 522-4 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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6-Ketoprostaglandin F1 alpha Endometrium / metabolism* Epoprostenol / pharmacology, physiology* Female Humans Menorrhagia / metabolism* Myometrium / metabolism Platelet Aggregation / drug effects Prostaglandins / physiology* Prostaglandins D / biosynthesis Prostaglandins E / biosynthesis Prostaglandins F / biosynthesis Vasodilation / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Prostaglandins; 0/Prostaglandins D; 0/Prostaglandins E; 0/Prostaglandins F; 35121-78-9/Epoprostenol; 58962-34-8/6-Ketoprostaglandin F1 alpha |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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