Document Detail

A role for prostacyclin (PGi2) in excessive menstrual bleeding.
MedLine Citation:
PMID:  6111633     Owner:  NLM     Status:  MEDLINE    
The synthesis of prostanoids from arachidonic acid incubated with endometrium alone or together with myometrium was studied in women with excessive menstrual blood-loss (range 57--186 ml, median 86 ml). Production of prostaglandins F2 alpha, E2, and D2 was similar to that observed for the endometrium of women with normal periods (range 5--50 ml; median 11 ml). However, the endometrium from women with excessive menstrual blood-loss was more effective than endometrium from women with normal menstrual blood-loss at enhancing the production by a control preparation of myometrium of 6-oxo-prostaglandin F1 alpha, the stable metabolite of prostacyclin. The ability of the uterus to generate prostacyclin, a prostaglandin known to inhibit platelet aggregation and stimulate vasodilatation, may influence the degree and duration of menstrual bleeding.
S K Smith; M H Abel; R W Kelly; D T Baird
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Lancet     Volume:  1     ISSN:  0140-6736     ISO Abbreviation:  Lancet     Publication Date:  1981 Mar 
Date Detail:
Created Date:  1981-06-13     Completed Date:  1981-06-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2985213R     Medline TA:  Lancet     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  522-4     Citation Subset:  AIM; IM    
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MeSH Terms
6-Ketoprostaglandin F1 alpha
Endometrium / metabolism*
Epoprostenol / pharmacology,  physiology*
Menorrhagia / metabolism*
Myometrium / metabolism
Platelet Aggregation / drug effects
Prostaglandins / physiology*
Prostaglandins D / biosynthesis
Prostaglandins E / biosynthesis
Prostaglandins F / biosynthesis
Vasodilation / drug effects
Reg. No./Substance:
0/Prostaglandins; 0/Prostaglandins D; 0/Prostaglandins E; 0/Prostaglandins F; 35121-78-9/Epoprostenol; 58962-34-8/6-Ketoprostaglandin F1 alpha

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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