| The role of preoptic area and anterior hypothalamus and median raphe nucleus on thermoregulatory system in freely moving rats. | |
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MedLine Citation:
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PMID: 11403973 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To clarify the role of the preoptic area and anterior hypothalamus (PO/AH) on thermoregulatory system and the effects of serotonergic innervation from the median raphe nucleus (MRN) on body temperature (Tb), we perfused tetrodotoxin (TTX) solution into the PO/AH or MRN by using a microdialysis technique at different ambient temperatures (5, 23 and 35 degrees C) in freely moving rats. Tb was continuously monitored by using a telemetry system. In the MRN, perfusion of TTX solution induced significant hypothermia in the normal environment, a greater decrease in Tb during cold exposure and had no effect on Tb during heat exposure. In the PO/AH, perfusion of TTX solution induced significant hyperthermia in normal environment, a greater increase in Tb during heat exposure and had no effect on Tb during cold exposure. Our results indicate that the PO/AH regulates mainly heat loss or inhibits the loci regulating heat production. Furthermore, heat production appears to be regulated by other loci receiving serotonergic innervation from the MRN. |
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Authors:
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T Ishiwata; H Hasegawa; M Yasumatsu; F Akano; T Yazawa; M Otokawa; Y Aihara |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Neuroscience letters Volume: 306 ISSN: 0304-3940 ISO Abbreviation: Neurosci. Lett. Publication Date: 2001 Jun |
Date Detail:
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Created Date: 2001-06-13 Completed Date: 2001-08-16 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 7600130 Medline TA: Neurosci Lett Country: Ireland |
Other Details:
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Languages: eng Pagination: 126-8 Citation Subset: IM |
Affiliation:
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Department of Biology, Faculty of Science, Tokyo Metropolitan University, 1-1 Minami-ohsawa, Hachioji, 192-0397, Tokyo, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anterior Hypothalamic Nucleus / drug effects, physiology* Body Temperature Regulation / drug effects, physiology* Cold Temperature / adverse effects Fever / chemically induced, physiopathology Hot Temperature / adverse effects Hypothermia / chemically induced, physiopathology Male Microdialysis Movement / drug effects, physiology Neural Pathways / drug effects, physiology* Neurons / drug effects, physiology* Pons / drug effects, physiology* Preoptic Area / drug effects, physiology* Raphe Nuclei / drug effects, physiology* Rats Rats, Wistar Tetrodotoxin / pharmacology |
| Chemical | |
Reg. No./Substance:
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4368-28-9/Tetrodotoxin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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