Document Detail

The role of preoperative subconjunctival mydricaine and topical diclofenac sodium 0.1% in maintaining mydriasis during vitrectomy.
MedLine Citation:
PMID:  10696747     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To establish the role of preoperative subconjunctival mydricaine and diclofenac 0.1% in maintaining mydriasis during vitrectomy. METHODS: Fifty-seven patients were entered into the study. All were given cyclopentolate 1% and phenylephrine 2.5% preoperatively. Each patient was randomly allocated to one of three groups. In Group 1, patients received mydricaine by subconjunctival injection and diclofenac 0.1% topically preoperatively. In Group 2, patients received only subconjunctival mydricaine. Group 3 patients received only topical diclofenac preoperatively. Pupil diameter was measured with calipers before and at the end of the operation. RESULTS: There was no statistically significant difference in the change in pupil size between Groups 2 and 3. In all patients in Group 1 (who received both subconjunctival mydricaine and diclofenac preoperatively), pupil size was either maintained or increased after vitrectomy. This result was statistically significant when compared with the other groups (for Group 1 versus Group 2, P<0.005; for Group 1 versus Group 3, P<4.7x10(-06)). CONCLUSION: Topical diclofenac is useful for maintaining pupil size during vitrectomy only when used in conjunction with subconjunctival mydricaine, especially in patients in whom prolonged surgery is anticipated.
M K Kulshrestha; S Rauz; R R Goble; I A Stavrakas; G R Kirkby
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Retina (Philadelphia, Pa.)     Volume:  20     ISSN:  0275-004X     ISO Abbreviation:  Retina (Philadelphia, Pa.)     Publication Date:  2000  
Date Detail:
Created Date:  2000-03-13     Completed Date:  2000-03-13     Revised Date:  2006-12-15    
Medline Journal Info:
Nlm Unique ID:  8309919     Medline TA:  Retina     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  46-51     Citation Subset:  IM    
Birmingham & Midland Eye Centre, Birmingham, UK.
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MeSH Terms
Aged, 80 and over
Anesthetics, Local / administration & dosage*
Atropine / administration & dosage
Cyclooxygenase Inhibitors / administration & dosage*
Diclofenac / administration & dosage*
Drug Combinations
Epinephrine / administration & dosage
Iris / drug effects*
Middle Aged
Mydriatics / administration & dosage*
Ophthalmic Solutions
Preoperative Care
Procaine / administration & dosage
Pupil / drug effects*
Treatment Outcome
Vitrectomy / methods*
Reg. No./Substance:
0/Anesthetics, Local; 0/Cyclooxygenase Inhibitors; 0/Drug Combinations; 0/Mydriatics; 0/Ophthalmic Solutions; 15307-86-5/Diclofenac; 51-43-4/Epinephrine; 51-55-8/Atropine; 59-46-1/Procaine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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