| The role of preoperative subconjunctival mydricaine and topical diclofenac sodium 0.1% in maintaining mydriasis during vitrectomy. | |
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MedLine Citation:
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PMID: 10696747 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To establish the role of preoperative subconjunctival mydricaine and diclofenac 0.1% in maintaining mydriasis during vitrectomy. METHODS: Fifty-seven patients were entered into the study. All were given cyclopentolate 1% and phenylephrine 2.5% preoperatively. Each patient was randomly allocated to one of three groups. In Group 1, patients received mydricaine by subconjunctival injection and diclofenac 0.1% topically preoperatively. In Group 2, patients received only subconjunctival mydricaine. Group 3 patients received only topical diclofenac preoperatively. Pupil diameter was measured with calipers before and at the end of the operation. RESULTS: There was no statistically significant difference in the change in pupil size between Groups 2 and 3. In all patients in Group 1 (who received both subconjunctival mydricaine and diclofenac preoperatively), pupil size was either maintained or increased after vitrectomy. This result was statistically significant when compared with the other groups (for Group 1 versus Group 2, P<0.005; for Group 1 versus Group 3, P<4.7x10(-06)). CONCLUSION: Topical diclofenac is useful for maintaining pupil size during vitrectomy only when used in conjunction with subconjunctival mydricaine, especially in patients in whom prolonged surgery is anticipated. |
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Authors:
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M K Kulshrestha; S Rauz; R R Goble; I A Stavrakas; G R Kirkby |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Retina (Philadelphia, Pa.) Volume: 20 ISSN: 0275-004X ISO Abbreviation: Retina (Philadelphia, Pa.) Publication Date: 2000 |
Date Detail:
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Created Date: 2000-03-13 Completed Date: 2000-03-13 Revised Date: 2006-12-15 |
Medline Journal Info:
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Nlm Unique ID: 8309919 Medline TA: Retina Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 46-51 Citation Subset: IM |
Affiliation:
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Birmingham & Midland Eye Centre, Birmingham, UK. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Aged, 80 and over Anesthetics, Local / administration & dosage* Atropine / administration & dosage Cyclooxygenase Inhibitors / administration & dosage* Diclofenac / administration & dosage* Drug Combinations Epinephrine / administration & dosage Female Humans Injections Iris / drug effects* Male Middle Aged Mydriatics / administration & dosage* Ophthalmic Solutions Preoperative Care Procaine / administration & dosage Pupil / drug effects* Treatment Outcome Vitrectomy / methods* |
| Chemical | |
Reg. No./Substance:
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0/Anesthetics, Local; 0/Cyclooxygenase Inhibitors; 0/Drug Combinations; 0/Mydriatics; 0/Ophthalmic Solutions; 15307-86-5/Diclofenac; 51-43-4/Epinephrine; 51-55-8/Atropine; 59-46-1/Procaine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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