| The role of polycomb group proteins in cell cycle regulation during development. | |
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MedLine Citation:
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PMID: 16721063 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Polycomb group (PcG) and trithorax group (trxG) proteins are evolutionarily conserved chromatin modifiers that have well known roles in the maintenance of silent and active expression states of homeotic genes. PcG proteins may also be involved in the control of cellular proliferation, as several PcG complexes have been shown to act either as proto-oncogenes or as tumor suppressors in vertebrates. In Drosophila, PcG factors associate with specific DNA regions termed PcG response elements (PREs), and a PRE was recently identified in the gene encoding Cyclin A. Still, it is not yet clear how PcG complexes could control cell cycle progression. Beyond acting as stable silencers of cell cycle genes during the differentiation process, PcG complexes might also be integrators and/or modulators of cell cycle checkpoints in dividing cells. Here, we discuss this dual aspect of PcG involvement in epigenetic cell cycle control. |
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Authors:
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Anne-Marie Martinez; Giacomo Cavalli |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2006-06-01 |
Journal Detail:
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Title: Cell cycle (Georgetown, Tex.) Volume: 5 ISSN: 1551-4005 ISO Abbreviation: Cell Cycle Publication Date: 2006 Jun |
Date Detail:
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Created Date: 2006-06-15 Completed Date: 2006-08-18 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 101137841 Medline TA: Cell Cycle Country: United States |
Other Details:
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Languages: eng Pagination: 1189-97 Citation Subset: IM |
Affiliation:
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Institute of Human Genetics, CNRS, Montpellier, France. Anne-Marie.Martinez@igh.cnrs.fr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Cycle / genetics, physiology* Drosophila Epigenesis, Genetic / physiology Growth and Development Repressor Proteins / physiology* |
| Chemical | |
Reg. No./Substance:
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0/Repressor Proteins; 0/polycomb group proteins |
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