Document Detail

The role of the placenta in iron transfer from mother to fetus and the relationship between iron status and fetal outcome.
MedLine Citation:
PMID:  12572675     Owner:  NLM     Status:  MEDLINE    
During pregnancy, iron is transferred from the mother to the fetus across the placenta. The mechanism has been extensively studied. Altered iron metabolism changes transfer, but also has other consequences. In this review, we examine how the placenta adapts to altered iron supply, both in terms of changing cytokine expression and in relation to the proteins of iron transfer. Changing iron levels alters the levels of other metals, especially copper, and we review how this is related to changing function. There are also consequences to the placenta itself, to vascularisation and other aspects of the physiology. In turn, this has effects on the fetus and we review how growth and development are modified. Finally, we examine in more detail the efflux process, how it is regulated and, especially, the putative role of the placental Cu oxidase in the efflux process. As appropriate, we draw on data from humans, from animal models and from cell culture systems to illustrate the information.
H J McArdle; R Danzeisen; C Fosset; L Gambling
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine     Volume:  16     ISSN:  0966-0844     ISO Abbreviation:  Biometals     Publication Date:  2003 Mar 
Date Detail:
Created Date:  2003-02-07     Completed Date:  2003-08-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9208478     Medline TA:  Biometals     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  161-7     Citation Subset:  IM    
The Rowett Research Institute, Greenburn Road, Bucksburn, Aberdeen, AB21 9SB, UK.
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MeSH Terms
Embryonic and Fetal Development / physiology*
Iron / deficiency,  metabolism*
Maternal-Fetal Exchange*
Models, Biological
Placenta / metabolism*
Reg. No./Substance:

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