| The role of the placenta in intrauterine growth restriction (IUGR). | |
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MedLine Citation:
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PMID: 19536707 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Intrauterine growth restriction (IUGR) represents a reduction from the physiological growth rate. Fetal growth depends from the maternal supply of nutrients through the placenta into the umbilical circulation. Consequently, fetal growth restriction is associated with a reduced nutritional placental supply and this can result from a decrease in utero-placental blood flows as well as a reduced placental transport capacity. In IUGR, the placental supply of amino acids is significantly reduced independently from the severity of growth restriction and from the presence of hypoxia. Moreover, maternal-fetal gradients of glucose are increased in severe IUGR fetuses, i. e. those with alterations of umbilical blood flows, and reduced conversion ratios of long chain-polyunsaturated fatty acids (LC-PUFA) from their parent fatty acids have been demonstrated. Mouse and human models suggest that epigenetic regulation of fetal growth may also play a significant role, through placental imprinted genes. This review summarizes the current knowledge about placental role in intrauterine growth restriction. |
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Authors:
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Irene Cetin; Patrizio Antonazzo |
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Publication Detail:
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Type: Journal Article; Review Date: 2009-06-17 |
Journal Detail:
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Title: Zeitschrift für Geburtshilfe und Neonatologie Volume: 213 ISSN: 1439-1651 ISO Abbreviation: Z Geburtshilfe Neonatol Publication Date: 2009 Jun |
Date Detail:
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Created Date: 2009-06-18 Completed Date: 2009-10-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9508901 Medline TA: Z Geburtshilfe Neonatol Country: Germany |
Other Details:
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Languages: eng Pagination: 84-8 Citation Subset: IM |
Affiliation:
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Unit of Obstetrics and Gynecology, Department of Clinical Sciences L. Sacco, University of Milan, Milano, Italy. irene.cetin@unimi.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Female Fetal Growth Retardation / physiopathology* Humans Maternal-Fetal Exchange* Models, Biological Placenta Diseases / physiopathology* Placental Circulation* Pregnancy |
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