Document Detail


The role of phospholipase A2 in the pathogenesis of respiratory damage in hemorrhagic necrotizing pancreatitis--assessment of a new experimental model.
MedLine Citation:
PMID:  11332353     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The new experimental model has been set as a standard with the purpose to explore and analyze the role of phospholipase A2 in predicting the severity of acute pancreatitis with specific interest for the onset of hemorrhagic necrotizing pancreatitis and pleuropulmonary complications. The experiments were performed on dogs (n = 25), and acute pancreatitis was induced with the injection of 10% sodium-taurocholate into pancreatic duct. Four experimental groups of animals were formed, so that 2 groups had lymph held by draining the thoracic duct. In the other two groups, the lymph had been put into system circulation, so that the nylon bag was set around the pancreas in order to prevent pancreatic juice to be spilt into abdominal cavity. The analyses of the levels of amylase, lipase, pancreatic amylase and phospholipase A2 in of serum, lymph and exudate were performed. The positive correlation was found between increased concentration of phospholipase A2 in serum and reduction of partial pressure of oxygen and pH of blood and the degree of severity of respiratory failure. The speed and intensity of development of the acute hemorrhagic necrotizing pancreatitis, as well as the severity of pulmonary complications might be estimated upon the of increase of the levels of phospholipase A2 in serum and lymph. This experimental model enables the studying of pathogenesis of acute pancreatitis and systemic complications.
Authors:
D Mirković
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Vojnosanitetski pregled. Military-medical and pharmaceutical review     Volume:  57     ISSN:  0042-8450     ISO Abbreviation:  Vojnosanit Pregl     Publication Date:    2000 Nov-Dec
Date Detail:
Created Date:  2001-05-02     Completed Date:  2001-05-31     Revised Date:  2008-01-09    
Medline Journal Info:
Nlm Unique ID:  21530700R     Medline TA:  Vojnosanit Pregl     Country:  Yugoslavia    
Other Details:
Languages:  eng     Pagination:  625-33     Citation Subset:  IM    
Affiliation:
Military Medical Academy, Clinic of General and Vascular Surgery, Belgrade.
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MeSH Terms
Descriptor/Qualifier:
Amylases / blood
Animals
Disease Models, Animal*
Dogs
Hemorrhage / complications*
Lipase / blood
Lung Diseases / etiology*
Lymph / enzymology
Pancreatitis, Acute Necrotizing / complications*,  enzymology,  physiopathology
Phospholipases A / blood*
Phospholipases A2
Chemical
Reg. No./Substance:
EC 3.1.1.-/Phospholipases A; EC 3.1.1.3/Lipase; EC 3.1.1.4/Phospholipases A2; EC 3.2.1.-/Amylases

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