Document Detail

The role of personality factors and suggestion in placebo effect during mental stress test.
MedLine Citation:
PMID:  1540479     Owner:  NLM     Status:  MEDLINE    
The aims of this study were first of all to document a placebo effect on systolic blood pressure and heart rate during mental arithmetic induced stress and secondly to assess the role of suggestion in producing this effect. Two types of placebo were used, a simple placebo and a placebo with an implied therapeutic action. Both were compared with alprazolam. A placebo response was seen in just over half of the volunteers when the cardiovascular changes to mental arithmetic induced stress in healthy volunteers were measured. This response appeared to be unaffected by the suggested therapeutic effect. Dominant, independent subjects, identified using the Cattell 16 PF personality test were less likely to respond to placebo. Alprazolam (0.5 mg) did not prevent, to a significantly greater degree than placebo, the systolic blood pressure or heart rate increases provoked by the mental stress.
C C McCann; B Goldfarb; M Frisk; M A Quera-Salva; P Meyer
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  British journal of clinical pharmacology     Volume:  33     ISSN:  0306-5251     ISO Abbreviation:  Br J Clin Pharmacol     Publication Date:  1992 Jan 
Date Detail:
Created Date:  1992-04-08     Completed Date:  1992-04-08     Revised Date:  2012-09-21    
Medline Journal Info:
Nlm Unique ID:  7503323     Medline TA:  Br J Clin Pharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  107-10     Citation Subset:  IM    
Clinical Pharmacology, Hôpital Necker, Paris, France.
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MeSH Terms
Alprazolam / adverse effects,  pharmacology*
Blood Pressure / drug effects*
Heart Rate / drug effects*
Placebo Effect
Stress, Psychological / physiopathology*
Reg. No./Substance:
0/Placebos; 28981-97-7/Alprazolam

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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