Document Detail


The role of peroxisome proliferator-activated receptor gamma in blood pressure regulation.
MedLine Citation:
PMID:  19602323     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Peroxisome proliferator-activated receptor-gamma (PPARgamma) is a member of the nuclear hormone receptor superfamily. It is expressed in adipocytes, immune cells, and cardiovascular cells that include cardiomyocytes, endothelial cells, and smooth muscle cells. PPARgamma plays a role in regulating cellular anti-inflammatory responses and is a mediator of insulin sensitization induced by thiazolidinediones, which also can reduce elevated blood pressure both clinically and experimentally. As a result, research regarding the role of PPARgamma in blood pressure homeostasis is ongoing. Recent studies have demonstrated that increases or decreases in blood pressure phenotype may be PPARgamma-dependent and involve a number of different signaling pathways. Furthermore, studies using PPARgamma mutant transgenic and knockout animal models provide further evidence regarding a role for endothelial-cell and vascular smooth muscle-cell PPARgamma in blood pressure regulation. However, there is a need for further research regarding PPARgamma--mediated mechanisms involved in maintaining physiologic control of blood pressure.
Authors:
Milton Hamblin; Lin Chang; Jifeng Zhang; Y Eugene Chen
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Current hypertension reports     Volume:  11     ISSN:  1534-3111     ISO Abbreviation:  Curr. Hypertens. Rep.     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2009-07-15     Completed Date:  2010-09-29     Revised Date:  2014-01-09    
Medline Journal Info:
Nlm Unique ID:  100888982     Medline TA:  Curr Hypertens Rep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  239-45     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adipocytes / drug effects
Angiotensin-Converting Enzyme Inhibitors / therapeutic use
Animals
Antihypertensive Agents / therapeutic use
Benzimidazoles / therapeutic use
Benzoates / therapeutic use
Blood Pressure*
Endothelium / drug effects
Hypertension / drug therapy*
Models, Animal
Myocytes, Cardiac / drug effects
Myocytes, Smooth Muscle / drug effects
PPAR gamma / drug effects*
Thiazolidinediones / therapeutic use*
Grant Support
ID/Acronym/Agency:
HL68878/HL/NHLBI NIH HHS; HL75397/HL/NHLBI NIH HHS; HL89544/HL/NHLBI NIH HHS; HL92421/HL/NHLBI NIH HHS; T32 HL007853/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Angiotensin-Converting Enzyme Inhibitors; 0/Antihypertensive Agents; 0/Benzimidazoles; 0/Benzoates; 0/PPAR gamma; 0/Thiazolidinediones; U5SYW473RQ/telmisartan

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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