Document Detail

The role of parenteral glutamine supplement for surgical patient perioperatively: result of a single center, prospective and controlled study.
MedLine Citation:
PMID:  18712409     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: We conducted a prospective and case-controlled study to evaluate the impact of supplement of alanyl-glutamine dipeptide (Gln) in parenteral nutrition on perioperative immune and nutritional changes and clinical outcomes for patients undergoing gastrointestinal (GI) operations.
MATERIALS AND METHODS: During 2006, 70 patients undergoing GI surgeries were allocated equally into two groups. One group received regular parenteral nutrition and the other received the same formulation and supplemented with the Gln; the two groups were isonitrogenous. The infusion was started from 1 day before operation to the sixth day after operation for 7 days. Blood samples were collected on the morning of the day before the operation and on the morning 6 days after the operation and analyzed for immune and nutrition parameters.
RESULTS: There were no differences between the two groups in terms of clinical characteristics, operative procedures, biochemistry, nutritional status, and immune status preoperatively. After GI surgery, significant reduction in nutritional and immune parameters were observed in both groups, demonstrated by significant difference of albumin, C-reactive protein (CRP), lymphocyte count, T cell, and CD8 cell. The length of hospital stay is slightly longer in the control group patients, but not to statistical significance (16.3 +/- 21.3 versus 12.2 +/- 6.8 days, p = 0.299). In terms of morbidity, there was no difference between the two groups, but two patients in the control group had wound infection; none was noted in the Gln group (p = 1.0). No surgical mortality was noted in this study.
CONCLUSIONS: Perioperative parenteral nutrition supplemented with Gln is beneficial for patients undergoing GI surgery. Gln supplementation significantly attenuated postoperative inflammation and ameliorated postoperative immunodepression as well as nutritional depression in GI surgery.
Chun-Nan Yeh; Hsiang-Lin Lee; Yu-Yin Liu; Kun-Chun Chiang; Tsann-Long Hwang; Yi-Yin Jan; Miin-Fu Chen
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2008-08-20
Journal Detail:
Title:  Langenbeck's archives of surgery / Deutsche Gesellschaft für Chirurgie     Volume:  393     ISSN:  1435-2451     ISO Abbreviation:  Langenbecks Arch Surg     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2008-10-07     Completed Date:  2009-05-11     Revised Date:  2013-05-27    
Medline Journal Info:
Nlm Unique ID:  9808285     Medline TA:  Langenbecks Arch Surg     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  849-55     Citation Subset:  IM    
Department of Surgery, Chang Gung Memorial Hospital, Chang Gung University, Kwei-Shan, Taoyuan, Taiwan.
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MeSH Terms
Case-Control Studies
Digestive System Diseases / immunology,  mortality,  surgery*
Digestive System Neoplasms / immunology,  mortality,  surgery*
Dipeptides / administration & dosage*
Hospital Mortality
Inflammation Mediators / blood
Infusions, Intravenous
Length of Stay
Lymphocyte Count
Lymphocyte Subsets / immunology
Middle Aged
Perioperative Care / methods*
Postoperative Complications / immunology,  mortality,  therapy
Prospective Studies
Survival Rate
Reg. No./Substance:
0/Dipeptides; 0/Inflammation Mediators; U5JDO2770Z/alanylglutamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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