Document Detail


The role of parental hypertension in the frequency and age of diagnosis of hypertension in offspring with autosomal-dominant polycystic kidney disease.
MedLine Citation:
PMID:  14531813     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Hypertension in autosomal-dominant polycystic kidney disease (ADPKD) patients is associated with more rapid progression of renal disease and a high incidence of left ventricular hypertrophy (LVH). The present study was undertaken to examine the role of parental hypertension in the occurrence of hypertension in 475 ADPKD offspring. METHODS: Adult subjects participating in an ongoing study of the natural history of ADPKD were included in the analysis if they were diagnosed with ADPKD, had a known affected parent, and knew the hypertensive status of both parents. RESULTS: When the affected parent was hypertensive, the ADPKD male (82% versus 62%, P < 0.05) and female (61% versus 37%, P < 0.005) offspring had a significantly higher frequency of hypertension than when the ADPKD-affected parent was normotensive. The median age of diagnosis of hypertension was also significantly earlier in both male (33 years versus 40 years, P < 0.05) and female (38 years versus 50 years, P < 0.05) ADPKD patients when their affected parents were hypertensive as compared with normotensive. These effects of hypertension in the affected parent on hypertension in the ADPKD offspring were independent of age, renal volume, and renal function in the offspring. Hypertension in unaffected parents also increased the frequency of hypertension in the ADPKD female (69% versus 53%, P < 0.01), but not male (89% versus 77%, NS) subjects. CONCLUSION: The results indicate that parental hypertension influences the frequency of hypertension in ADPKD patients.
Authors:
Robert W Schrier; Ann M Johnson; Kim McFann; Arlene B Chapman
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Kidney international     Volume:  64     ISSN:  0085-2538     ISO Abbreviation:  Kidney Int.     Publication Date:  2003 Nov 
Date Detail:
Created Date:  2003-10-08     Completed Date:  2004-06-24     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0323470     Medline TA:  Kidney Int     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1792-9     Citation Subset:  IM    
Affiliation:
Department of Medicine, University of Colorado School of Medicine, Denver, Colorado 80262, USA. Robert.Schrier@uchsc.edu
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MeSH Terms
Descriptor/Qualifier:
Adult
Blood Pressure
Female
Humans
Hypertension, Renal / diagnosis*,  genetics*,  mortality
Male
Medical History Taking
Middle Aged
Multivariate Analysis
Parents
Polycystic Kidney, Autosomal Dominant / diagnosis*,  genetics*,  mortality
Survival Analysis
Grant Support
ID/Acronym/Agency:
5 PO1 DK34039/DK/NIDDK NIH HHS; M0RR-00051/RR/NCRR NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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