Document Detail

The role of p53, Bcl-2 and Ki-67 in premalignant cervical lesions and cervical cancer.
MedLine Citation:
PMID:  17713095     Owner:  NLM     Status:  MEDLINE    
PURPOSE: The aim of this study was to determine the role of p53, Bcl-2 and Ki-67 expression in the carcinogenesis of cervical carcinoma and aggressiveness of cervical intraepithelial neoplasia (CIN). METHODS: The pathology specimens of 63 patients with a diagnosis of normal squamous epithelium (22 cases), CIN I (14), CIN II (5), CIN III (8) and squamous cell carcinoma (14) were evaluated immunohistochemically for the expression of p53, Bcl-2 and Ki-67 in paraffin sections. RESULTS: The expression of p53 and Ki-67 increased proportionally to the grade of CIN and cervical cancer, but only the increase of p53 expression was statistically significant (p = 0.002). There was no significant correlation between Bcl-2 expression and premalignant and malignant cervical lesions. CONCLUSION: p53 expression may have a role in the carcinogenesis of squamous cell cervical carcinoma whereas Bcl-2 expression has no role. Ki-67 expression can not be used in determining the aggressiveness of CIN lesions.
I Türkçüoğlu; S Tezcan; G Kaygusuz; C Somer Atabekoğlu; F Ortaç; M Güngör; D Kankaya; A Sertçelik
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of gynaecological oncology     Volume:  28     ISSN:  0392-2936     ISO Abbreviation:  Eur. J. Gynaecol. Oncol.     Publication Date:  2007  
Date Detail:
Created Date:  2007-08-23     Completed Date:  2007-09-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8100357     Medline TA:  Eur J Gynaecol Oncol     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  290-3     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Ankara University School of Medicine, Ankara, Turkey.
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MeSH Terms
Cervical Intraepithelial Neoplasia / classification,  pathology*
Ki-67 Antigen / metabolism*
Proto-Oncogene Proteins c-bcl-2 / metabolism*
Tumor Suppressor Protein p53 / metabolism*
Uterine Cervical Neoplasms / classification,  pathology*
Reg. No./Substance:
0/Ki-67 Antigen; 0/Proto-Oncogene Proteins c-bcl-2; 0/Tumor Suppressor Protein p53

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