Document Detail

A role for oxygen-induced osmosis in hyperbaric oxygen therapy.
MedLine Citation:
PMID:  10362286     Owner:  NLM     Status:  MEDLINE    
The principles of gas-induced osmosis, demonstrated in the 1970s, have been applied to the very large steady-state gradients of O2 arising between arterial blood and hypoxic tissue during hyperbaric oxygen (HBO) therapy to produce a fluid 'pump' in the desired direction for resolving accompanying oedema. Thus, in soft-tissue injuries, an oxygen-induced fluid pump would break the vicious cycle between ischaemia, hypoxia and oedema at the point of oedema rather than hypoxia, as hitherto assumed. This osmotic mechanism enables the successes of HBO therapy in hypoxic disorders to be reconciled with early failures in such areas as hyperbaric radiotherapy, where substitution of O2 for N2 in inspired air was clearly not reflected at the tissue level. This argument also applies to the success of HBO in treating air embolism and decompression sickness over simple compression. The oxygen pump would seem to offer a more plausible explanation for the success of HBO therapy than theories based upon O2 delivery by the circulation, especially when considering cardiovascular reflexes to elevated PaO2 and the marginal increase in blood O2 content upon switching to HBO from normobaric oxygen breathing.
B A Hills
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Medical hypotheses     Volume:  52     ISSN:  0306-9877     ISO Abbreviation:  Med. Hypotheses     Publication Date:  1999 Mar 
Date Detail:
Created Date:  1999-07-22     Completed Date:  1999-07-22     Revised Date:  2008-08-15    
Medline Journal Info:
Nlm Unique ID:  7505668     Medline TA:  Med Hypotheses     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  259-63     Citation Subset:  IM    
Paediatric Respiratory Research Centre, Mater Children's Hospital, Brisbane, Australia.
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MeSH Terms
Anoxia / physiopathology,  therapy*
Edema / physiopathology
Hyperbaric Oxygenation*
Ischemia / physiopathology
Models, Biological*
Oxygen / blood*
Oxygen Consumption*
Reg. No./Substance:

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