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The role of oxidative stress and the effects of antioxidants on the incidence of infectious complications of chronic lymphocytic leukemia.
MedLine Citation:
PMID:  25383139     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Chronic lymphocytic leukemia (CLL) is characterized by a predominant humoral immune deficiency predisposing the patients to infections. Oxidative stress leads to an increased immunoglobulin k light chain production in B cells and contributes to the antibodies' deficiency and hypogammaglobulinemia. Aim of the Study. To evaluate the global oxidative status in patients with CLL and to determine whether the administration of antioxidants decreases complications due to infections. Patients and Method. We studied 84 patients with CLL stratified by Binet staging. Free oxygen radicals and antioxidant status were determined by the FORT and FORD test, respectively, at diagnosis and in the presence of infections. The patients were distributed in two groups: group A, treated only with antileukemic treatment, and group B, treated with antileukemic treatment and antioxidants. Results. By FORD and FORT assay, all patients had at diagnosis a low antioxidant capacity, and high levels of hydroperoxides. Infectious complications were more frequent in group A (B/C stages of disease) than in group B. Administrations of antioxidants stimulated the immune response and decreased infectious complications in CLL. Conclusions. Administrations of antioxidants and a healthy life style may improve the quality of life of patients with CLL and reduce the risk of infectious complications.
Authors:
Amelia Maria Gaman; Ana-Maria Buga; Mihnea-Alexandru Gaman; Aurel Popa-Wagner
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Publication Detail:
Type:  Journal Article     Date:  2014-10-14
Journal Detail:
Title:  Oxidative medicine and cellular longevity     Volume:  2014     ISSN:  1942-0994     ISO Abbreviation:  Oxid Med Cell Longev     Publication Date:  2014  
Date Detail:
Created Date:  2014-11-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101479826     Medline TA:  Oxid Med Cell Longev     Country:  United States    
Other Details:
Languages:  eng     Pagination:  158135     Citation Subset:  IM    
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