| The role of osmic acid in the treatment of immune synovitis. | |
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MedLine Citation:
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PMID: 942503 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Thirty-seven New Zealand rabbits were observed for up to 1 year after their knee joints were instilled with 1 ml of 1% osmic acid. A selective destruction of synovial lining cells occurred with a concurrent synovitis, but lining cell regenerated by the eighth week. Nonprogressive abnormalities were also present in the cartilage. When an immune synovitis was induced in both knees of 16 rabbits, the osmic acid treated joint demonstrated a significantly greater synovitis and progressive aberrations compared to the untreated knee. |
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Authors:
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V M Goldberg; R Rashbaum; J Zika |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Arthritis and rheumatism Volume: 19 ISSN: 0004-3591 ISO Abbreviation: Arthritis Rheum. Publication Date: 1976 Jul-Aug |
Date Detail:
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Created Date: 1976-09-25 Completed Date: 1976-09-25 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0370605 Medline TA: Arthritis Rheum Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 737-42 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arthritis, Rheumatoid / drug therapy Autoradiography Cartilage, Articular / pathology Cathepsins / metabolism Disease Models, Animal* Injections, Intra-Articular Knee Joint / enzymology, immunology Osmium / administration & dosage, therapeutic use* Rabbits Synovitis / drug therapy*, immunology, pathology |
| Chemical | |
Reg. No./Substance:
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7440-04-2/Osmium; EC 3.4.-/Cathepsins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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