Document Detail


The role of osmic acid in the treatment of immune synovitis.
MedLine Citation:
PMID:  942503     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Thirty-seven New Zealand rabbits were observed for up to 1 year after their knee joints were instilled with 1 ml of 1% osmic acid. A selective destruction of synovial lining cells occurred with a concurrent synovitis, but lining cell regenerated by the eighth week. Nonprogressive abnormalities were also present in the cartilage. When an immune synovitis was induced in both knees of 16 rabbits, the osmic acid treated joint demonstrated a significantly greater synovitis and progressive aberrations compared to the untreated knee.
Authors:
V M Goldberg; R Rashbaum; J Zika
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Arthritis and rheumatism     Volume:  19     ISSN:  0004-3591     ISO Abbreviation:  Arthritis Rheum.     Publication Date:    1976 Jul-Aug
Date Detail:
Created Date:  1976-09-25     Completed Date:  1976-09-25     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0370605     Medline TA:  Arthritis Rheum     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  737-42     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Arthritis, Rheumatoid / drug therapy
Autoradiography
Cartilage, Articular / pathology
Cathepsins / metabolism
Disease Models, Animal*
Injections, Intra-Articular
Knee Joint / enzymology,  immunology
Osmium / administration & dosage,  therapeutic use*
Rabbits
Synovitis / drug therapy*,  immunology,  pathology
Chemical
Reg. No./Substance:
7440-04-2/Osmium; EC 3.4.-/Cathepsins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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