| The role of oral L-carnitine therapy in chronic hemodialysis patients. | |
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MedLine Citation:
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PMID: 20427868 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To evaluate the effects of L-carnitine oral supplementation on anemia and cardiac function in patients on maintenance hemodialysis (HD), we studied 55 adult chronic HD patients at our center during the period from January 2006 to June 2006 and divided them into two groups; a group of 20 patients who received 1500 mg/day oral L-carnitine and a control group of 35 patients. Both groups were on erythropoietin therapy. Echogardiographic studies were performed before and at the end of the study. The mean hemoglobin levels were comparable in the L-carnitine group and the control group at the start and after 6 months of therapy (8.63 +/- 1.77 and 9.39 +/- 2.02 gm/dL, P = 0.18; 10.49 +/- 1.65 and 10.92 +/- 2.48 gm/dL, P = 0.76, respectively). The mean weekly maintenance dose of erythropoietin was not statistically significantly different in L-carnitine group (80.16 +/- 35.61 units/kg) and the control group (91.9 +/- 38.21 units/kg, P = 0.20). In addition no significant improvement could be observed in the echogardiographic findings in the L-carnitine group after therapy. We conclude that our study revealed no significant improvement in hemoglobin, erythropoietin dose and echocardiographic findings after six months of therapy. Long-term studies including larger number of patients are required to clarify the questionable role of L-carnitine in the HD patients. |
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Authors:
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Alaa A Sabry |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia Volume: 21 ISSN: 1319-2442 ISO Abbreviation: Saudi J Kidney Dis Transpl Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-07-19 Completed Date: 2010-08-12 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9436968 Medline TA: Saudi J Kidney Dis Transpl Country: Saudi Arabia |
Other Details:
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Languages: eng Pagination: 454-9 Citation Subset: IM |
Affiliation:
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Nephrology Department, Urology and Nephrology Center, Mansoura University, Egypt. asabry2040@yahoo.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Adult Anemia / blood, drug therapy, etiology Carnitine / administration & dosage* Chronic Disease Dietary Supplements* Echocardiography Egypt Erythropoietin / administration & dosage Female Hematinics / administration & dosage Hemoglobins / metabolism Humans Kidney Diseases / blood, complications, drug therapy, physiopathology, therapy* Male Middle Aged Renal Dialysis* Time Factors Treatment Outcome Ventricular Function / drug effects Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Hematinics; 0/Hemoglobins; 11096-26-7/Erythropoietin; 541-15-1/Carnitine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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