| The role of omega-3 fatty acids in the secondary prevention of cardiovascular disease. | |
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MedLine Citation:
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PMID: 12881589 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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It has long been recognized from epidemiological studies that Greenland Eskimos have substantially reduced rates of acute myocardial infarction (MI) compared with Western controls. From these epidemiological observations, the benefits of fatty fish consumption have been explored in cell culture and animal studies, as well as randomized controlled trials investigating the cardioprotective effects of omega-3 fatty acids. Dietary omega-3 fatty acids seem to stabilize the myocardium electrically, resulting in reduced susceptibility to ventricular arrhythmias, thereby reducing the risk of sudden death. These fatty acids also have potent anti-inflammatory effects, and may also be antithrombotic and anti-atherogenic. Furthermore, the recent GISSI-Prevention study of 11 324 patients showed a marked decrease in risk of sudden cardiac death as well as a reduction in all-cause mortality in the group taking a highly purified form of omega-3 fatty acids, despite the use of other secondary prevention drugs, including beta-blockers and lipid-lowering therapy. The use of omega-3 fatty acids should be considered as part of a comprehensive secondary prevention strategy post-myocardial infarction. |
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Authors:
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K W Lee; G Y H Lip |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: QJM : monthly journal of the Association of Physicians Volume: 96 ISSN: 1460-2725 ISO Abbreviation: QJM Publication Date: 2003 Jul |
Date Detail:
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Created Date: 2003-07-25 Completed Date: 2003-09-04 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 9438285 Medline TA: QJM Country: England |
Other Details:
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Languages: eng Pagination: 465-80 Citation Subset: IM |
Affiliation:
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Haemostasis, Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arrhythmias, Cardiac / prevention & control Coronary Disease / diet therapy, prevention & control* Dogs Fatty Acids, Omega-3 / administration & dosage, pharmacology* Female Forecasting Humans Linoleic Acid / physiology Male Nutritional Physiological Phenomena / physiology Randomized Controlled Trials as Topic Rats Risk Factors Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Fatty Acids, Omega-3; 2197-37-7/Linoleic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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