Document Detail

The role of nutrition and chemoprevention in colorectal cancer: from observations to expectations.
MedLine Citation:
PMID:  11969234     Owner:  NLM     Status:  MEDLINE    
During the last 20 years the role of aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs) in reducing the risk of colorectal cancer was shown in more than 100 animal studies. Support derives from 23 of 25 epidemiological studies confirming this protective effect. The COX-2 specific inhibitors and the selective apoptotic anti-neoplastic drugs offer the benefit of cancer protection without the gastrointestinal toxicity that was reported for the 'old' drugs. The presence of multiple molecular targets offers the potential for combination. The pivotal question in the puzzle of NSAID chemopreventive treatment should not be 'if' but 'how'. The concept that different food components may initiate or prevent cancer was illustrated by different epidemiological studies and animal models. Yet the chemical and biological complexity of the food, the difficulty in measuring habitual diets and the unavoidable changes in food constituents following a specific change in diet all contribute to this complexity.
Nachum Vaisman; Nadir Arber
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Best practice & research. Clinical gastroenterology     Volume:  16     ISSN:  1521-6918     ISO Abbreviation:  Best Pract Res Clin Gastroenterol     Publication Date:  2002 Apr 
Date Detail:
Created Date:  2002-04-23     Completed Date:  2002-10-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  101120605     Medline TA:  Best Pract Res Clin Gastroenterol     Country:  England    
Other Details:
Languages:  eng     Pagination:  201-17     Citation Subset:  IM    
Copyright Information:
Copyright 2002 Elsevier Science Ltd.
Nutrition Unit, Department of Gastroenterology, Tel Aviv Sourasky Medical Center, Sackler School of Medicine, Tel Aviv University, Israel.
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MeSH Terms
Anti-Inflammatory Agents, Non-Steroidal / pharmacology*,  therapeutic use
Colorectal Neoplasms / diet therapy,  drug therapy,  prevention & control*
Cyclooxygenase Inhibitors / pharmacology*,  therapeutic use
Dietary Carbohydrates / adverse effects
Dietary Fats / adverse effects
Dietary Fiber / pharmacology
Disease Models, Animal
Health Behavior
Micronutrients / pharmacology
Risk Factors
Reg. No./Substance:
0/Anti-Inflammatory Agents, Non-Steroidal; 0/Cyclooxygenase Inhibitors; 0/Dietary Carbohydrates; 0/Dietary Fats; 0/Micronutrients

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