Document Detail

The role of nucleus accumbens adenosine-opioid interaction in mediating palatable food intake.
MedLine Citation:
PMID:  19822132     Owner:  NLM     Status:  MEDLINE    
Nucleus accumbens micro-opioid stimulation leads to robust increases in the intake of highly palatable foods, such as a high-fat diet. While interactions between opioids and certain striatal neurotransmitters underlying this phenomenon have been explored, many potential interactions have not. Striatal adenosine has been shown to have a significant influence on striatal neurotransmission and locomotor activity behavior, however the interaction between opioids and adenosine on feeding behaviors has received less attention. The present study explored this interaction within the context of opioid-driven consumption of a high-fat diet. Specifically, intra-accumbens administration of selective A1 and A2(A) adenosine receptor ligands, with or without concurrent administration of the micro-opioid agonist (D)-Ala(2),N,Me-Phe(4),Gly-ol(5)-enkaphalin (DAMGO), on high-fat consumption and associated locomotor activity was examined. The A1 receptor agonist 2-Chloro-N6-cyclopentyladenosine (CCPA) had no effect on either baseline or DAMGO-induced locomotor or consumption behaviors associated with the high-fat diet. However, the A2(A) receptor agonist 2-p-(2 carboxyethyl)-phenethylamino-5'-N-ethylcarboxamido adenosine hydrochloride (CGS 21680) and the prodrug of the A2(A) receptor antagonist MSX-2, 3-(3-hydroxypropyl)-8-(m-methoxystyryl)-7-methyl-1-propargylxanthine phosphate disodium salt (MSX-3) produced the expected decrease and increase in locomotor activity, respectively. CGS 21680 had no effect on baseline or DAMGO-driven consumption of the high-fat diet. MSX-3 had no effect on DAMGO-induced locomotor activity but increased DAMGO-induced consumption. Lastly, the increased activity and consumption produced by MSX-3 alone was blocked by prior administration of the opioid antagonist naltrexone. In summary, these results suggest a potential role of striatal adenosine A2(A) receptors in mediating baseline and striatal opioid-mediated intake of a high-fat diet.
Carolyn E Pritchett; Alicia L Pardee; Sophia R McGuirk; Matthew J Will
Publication Detail:
Type:  Journal Article     Date:  2009-10-12
Journal Detail:
Title:  Brain research     Volume:  1306     ISSN:  1872-6240     ISO Abbreviation:  Brain Res.     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2009-11-27     Completed Date:  2010-02-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  85-92     Citation Subset:  IM    
Department of Neural and Behavioral Sciences, Penn State College of Medicine, Hershey, PA 17033, USA.
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MeSH Terms
Adenosine / analogs & derivatives,  pharmacology
Central Nervous System Agents / pharmacology
Dietary Fats*
Eating / drug effects,  physiology*
Enkephalin, Ala(2)-MePhe(4)-Gly(5)- / pharmacology
Locomotion / drug effects,  physiology
Naltrexone / pharmacology
Narcotic Antagonists / pharmacology
Nucleus Accumbens / drug effects,  physiology*
Phenethylamines / pharmacology
Rats, Sprague-Dawley
Receptor, Adenosine A1 / agonists,  metabolism*
Receptor, Adenosine A2A / agonists,  antagonists & inhibitors,  metabolism*
Receptors, Opioid, mu / agonists,  antagonists & inhibitors,  metabolism*
Xanthines / pharmacology
Reg. No./Substance:
0/Central Nervous System Agents; 0/Dietary Fats; 0/MSX 3 compound; 0/Narcotic Antagonists; 0/Phenethylamines; 0/Receptor, Adenosine A1; 0/Receptor, Adenosine A2A; 0/Receptors, Opioid, mu; 0/Xanthines; 100929-53-1/Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; 120225-54-9/CGS 21680; 16590-41-3/Naltrexone; 37739-05-2/2-chloro-N(6)cyclopentyladenosine; 58-61-7/Adenosine

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