Document Detail

The role of noninvasive imaging techniques in the assessment of stem cell therapy after acute myocardial infarction.
MedLine Citation:
PMID:  16501629     Owner:  NLM     Status:  MEDLINE    
Stem cell therapy after acute myocardial infarction is a promising therapeutic strategy. Intermediate-sized clinical trials to answer many unanswered questions must be carefully designed and surrogate end points carefully chosen. Moreover, imaging techniques accurate enough to measure surrogate parameters and to make it possible to reduce sample size are needed. The imaging technique of choice in this setting should be capable of tracking the destiny of the stem cells once injected in the heart and of quantifying left ventricular remodelling parameters. This information will be crucial in the design of multicenter, large, randomized trials to assess survival, which can definitively establish the usefulness of this therapeutic strategy.
José Alberto San Román; Francisco Fernández-Avilés
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Nature clinical practice. Cardiovascular medicine     Volume:  3 Suppl 1     ISSN:  1743-4297     ISO Abbreviation:  -     Publication Date:  2006 Mar 
Date Detail:
Created Date:  2006-02-27     Completed Date:  2006-11-08     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  101226507     Medline TA:  Nat Clin Pract Cardiovasc Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  S38-41     Citation Subset:  IM    
Imaging Unit, Institute of Heart Sciences (ICICOR), Hospital Clínico Universitario, Valladolid, Spain.
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MeSH Terms
Cell Movement
Endpoint Determination
Heart Function Tests
Magnetic Resonance Imaging* / methods
Myocardial Infarction / pathology,  therapy*
Randomized Controlled Trials as Topic
Research Design
Stem Cell Transplantation*
Stem Cells
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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