| The role of the non-invasive serum marker FibroTest-ActiTest in the prediction of histological stage of fibrosis and activity in children with naïve chronic hepatitis B infection. | |
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MedLine Citation:
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PMID: 20429710 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of this study was to investigate whether the non-invasive serum marker FibroTest-ActiTest (FT-AT) reliably predicts the histological stage of fibrosis and/or activity, and decreases the need for a liver biopsy. Twenty-five children with naïve chronic hepatitis B were analyzed for haptoglobin, alpha2-macroglobulin, apolipoprotein A1, bilirubin, gamma-glutamyl transferase, and alanine aminotransferase activity, and the FT-AT scores were computed. FT-AT scores were compared with histological data. FT predicted insignificant fibrosis in 14/23 (61%) patients at a cut-off level of 0.31. Nine patients (36%) had significant histological fibrosis, but none were predicted by FT. There was no correlation between FT scores and histological stage of fibrosis (r: -0.221, p = 0.228). All 4 patients with significant histological activity had corresponding significant activity in AT (100%). Fifteen out of the 19 patients (78.9%) with significant activity in AT had insignificant histological activity. At the cut-off level of 0.36, AT predicted insignificant activity in all 6 patients (100%). There was no correlation between AT scores and histological activity (r: 0.245, p = 0.237). According to histological data, 12 patients were candidates for treatment, but FT-AT did not predict 3 of them (25%). FT-AT does not appear ready for use in detecting either the stage of fibrosis or activity in children with chronic hepatitis B. |
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Authors:
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Semra Sökücü; Selim Gökçe; Mine Güllüoğlu; Ayşen Aydoğan; Coşkun Celtik; Ozlem Durmaz |
Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Scandinavian journal of infectious diseases Volume: 42 ISSN: 1651-1980 ISO Abbreviation: Scand. J. Infect. Dis. Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-08-25 Completed Date: 2010-12-27 Revised Date: 2011-02-03 |
Medline Journal Info:
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Nlm Unique ID: 0215333 Medline TA: Scand J Infect Dis Country: England |
Other Details:
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Languages: eng Pagination: 699-703 Citation Subset: IM |
Affiliation:
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Department of Paediatric Gastroenterology, Istanbul University, Istanbul,Turkey. semraso@hotmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Biological Markers / blood Biopsy, Needle / methods* Blood Proteins / analysis* Child Child, Preschool Cohort Studies Disease Progression Female Hepatitis B, Chronic / blood*, diagnosis, pathology Humans Liver Cirrhosis / blood*, diagnosis, pathology, virology Liver Function Tests / methods* Male Predictive Value of Tests Sample Size |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Blood Proteins |
| Comments/Corrections | |
Comment In:
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Scand J Infect Dis. 2011 Feb;43(2):159-60
[PMID:
21235307
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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