Document Detail


The role of the non-invasive serum marker FibroTest-ActiTest in the prediction of histological stage of fibrosis and activity in children with naïve chronic hepatitis B infection.
MedLine Citation:
PMID:  20429710     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aim of this study was to investigate whether the non-invasive serum marker FibroTest-ActiTest (FT-AT) reliably predicts the histological stage of fibrosis and/or activity, and decreases the need for a liver biopsy. Twenty-five children with naïve chronic hepatitis B were analyzed for haptoglobin, alpha2-macroglobulin, apolipoprotein A1, bilirubin, gamma-glutamyl transferase, and alanine aminotransferase activity, and the FT-AT scores were computed. FT-AT scores were compared with histological data. FT predicted insignificant fibrosis in 14/23 (61%) patients at a cut-off level of 0.31. Nine patients (36%) had significant histological fibrosis, but none were predicted by FT. There was no correlation between FT scores and histological stage of fibrosis (r: -0.221, p = 0.228). All 4 patients with significant histological activity had corresponding significant activity in AT (100%). Fifteen out of the 19 patients (78.9%) with significant activity in AT had insignificant histological activity. At the cut-off level of 0.36, AT predicted insignificant activity in all 6 patients (100%). There was no correlation between AT scores and histological activity (r: 0.245, p = 0.237). According to histological data, 12 patients were candidates for treatment, but FT-AT did not predict 3 of them (25%). FT-AT does not appear ready for use in detecting either the stage of fibrosis or activity in children with chronic hepatitis B.
Authors:
Semra Sökücü; Selim Gökçe; Mine Güllüoğlu; Ayşen Aydoğan; Coşkun Celtik; Ozlem Durmaz
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Scandinavian journal of infectious diseases     Volume:  42     ISSN:  1651-1980     ISO Abbreviation:  Scand. J. Infect. Dis.     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-08-25     Completed Date:  2010-12-27     Revised Date:  2011-02-03    
Medline Journal Info:
Nlm Unique ID:  0215333     Medline TA:  Scand J Infect Dis     Country:  England    
Other Details:
Languages:  eng     Pagination:  699-703     Citation Subset:  IM    
Affiliation:
Department of Paediatric Gastroenterology, Istanbul University, Istanbul,Turkey. semraso@hotmail.com
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Biological Markers / blood
Biopsy, Needle / methods*
Blood Proteins / analysis*
Child
Child, Preschool
Cohort Studies
Disease Progression
Female
Hepatitis B, Chronic / blood*,  diagnosis,  pathology
Humans
Liver Cirrhosis / blood*,  diagnosis,  pathology,  virology
Liver Function Tests / methods*
Male
Predictive Value of Tests
Sample Size
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Blood Proteins
Comments/Corrections
Comment In:
Scand J Infect Dis. 2011 Feb;43(2):159-60   [PMID:  21235307 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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