Document Detail

The role of nitrogen oxides in human adaptation to hypoxia.
MedLine Citation:
PMID:  22355626     Owner:  NLM     Status:  MEDLINE    
Lowland residents adapt to the reduced oxygen availability at high altitude through a process known as acclimatisation, but the molecular changes underpinning these functional alterations are not well understood. Using an integrated biochemical/whole-body physiology approach we here show that plasma biomarkers of NO production (nitrite, nitrate) and activity (cGMP) are elevated on acclimatisation to high altitude while S-nitrosothiols are initially consumed, suggesting multiple nitrogen oxides contribute to improve hypoxia tolerance by enhancing NO availability. Unexpectedly, oxygen cost of exercise and mechanical efficiency remain unchanged with ascent while microvascular blood flow correlates inversely with nitrite. Our results suggest that NO is an integral part of the human physiological response to hypoxia. These findings may be of relevance not only to healthy subjects exposed to high altitude but also to patients in whom oxygen availability is limited through disease affecting the heart, lung or vasculature, and to the field of developmental biology.
Denny Z Levett; Bernadette O Fernandez; Heather L Riley; Daniel S Martin; Kay Mitchell; Carl A Leckstrom; Can Ince; Brian J Whipp; Monty G Mythen; Hugh E Montgomery; Mike P Grocott; Martin Feelisch;
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-10-06
Journal Detail:
Title:  Scientific reports     Volume:  1     ISSN:  2045-2322     ISO Abbreviation:  Sci Rep     Publication Date:  2011  
Date Detail:
Created Date:  2012-02-22     Completed Date:  2013-08-01     Revised Date:  2014-02-20    
Medline Journal Info:
Nlm Unique ID:  101563288     Medline TA:  Sci Rep     Country:  England    
Other Details:
Languages:  eng     Pagination:  109     Citation Subset:  IM    
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MeSH Terms
Adaptation, Physiological*
Anoxia / metabolism,  physiopathology*
Nitrogen Oxides / metabolism*
Regional Blood Flow
Grant Support
G0701115//Medical Research Council
Reg. No./Substance:
0/Nitrogen Oxides

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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