Document Detail

The role of nitric oxide synthase in cortical plasticity is sex specific.
MedLine Citation:
PMID:  23100421     Owner:  NLM     Status:  MEDLINE    
Nitric oxide synthase-1 (NOS1) is involved in several forms of plasticity including hippocampal-dependent learning and memory, experience-dependent plasticity in the barrel cortex, and long-term potentiation (LTP) in the hippocampus and neocortex. NOS1 also contributes to ischemic damage during stroke and has a stronger deleterious effect in males than females. We therefore investigated whether the role of NOS1 in plasticity might also be sex specific. We tested LTP in the layer IV-II/III pathway between barrel columns and experience-dependent plasticity in the barrel cortex of αNOS1 knock-out mice and their wild-type littermates. We found that LTP was absent in male αNOS1 knock-out mice but not in females and that the residual LTP in females was not NO dependent. We also found that experience-dependent potentiation due to single whisker experience was significantly reduced in male αNOS1 knockouts but was unaffected in females. The αNOS1 knockout had a small effect on the development of the barrels, which were reduced in size by 20% compared with wild types, but this effect was not sex specific. We therefore conclude that neocortical plasticity mechanisms differ between males and females at the synaptic level, either in their basic plasticity induction pathways or in their ability to compensate for loss of αNOS1.
James Dachtler; Neil R Hardingham; Kevin Fox
Publication Detail:
Type:  In Vitro; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of neuroscience : the official journal of the Society for Neuroscience     Volume:  32     ISSN:  1529-2401     ISO Abbreviation:  J. Neurosci.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-26     Completed Date:  2013-01-07     Revised Date:  2014-02-20    
Medline Journal Info:
Nlm Unique ID:  8102140     Medline TA:  J Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  14994-9     Citation Subset:  IM    
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MeSH Terms
Cerebral Cortex / cytology,  physiology*
Electric Stimulation
Long-Term Potentiation / genetics,  physiology*
Mice, Inbred C57BL
Mice, Knockout
Nitric Oxide Synthase Type I / deficiency,  metabolism*
Sensory Deprivation / physiology
Sex Characteristics*
Vibrissae / innervation
Grant Support
G0901299//Medical Research Council; P50 MH077972/MH/NIMH NIH HHS; //Medical Research Council
Reg. No./Substance:
EC Oxide Synthase Type I; EC protein, mouse

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