Document Detail

The role of nitric oxide in pediatric patients with portal hypertension.
MedLine Citation:
PMID:  12630718     Owner:  NLM     Status:  MEDLINE    
The hyperdynamic circulation of cirrhosis and portal hypertension has been postulated to be due to the vasodilatory effects of nitric oxide. However, there have been conflicting results in adults and no studies in children. We aimed to measure the nitric oxide level in serum of pediatric patients with portal hypertension with and without cirrhosis, in order to assess its role in the development of hemodynamic changes. We measured nitric oxide levels in 41 pediatric patients (21 patients with intrahepatic portal hypertension and 20 with extrahepatic portal hypertension). The mean age of the study population was 11.2 +/- 4.6 years; 53 per cent were female. Twenty healthy children were included as a control group. Nitric oxide levels were measured by Boehringer-Mannheim colorimetric assay and the statistical significance was calculated by Kruskal-Wallis one-way ANOVA. Significantly higher nitric oxide levels were found in patients independent of the type of portal hypertension compared with the control group (29.4 +/- 6 in patients with intrahepatic portal hypertension, 29.5 +/- 5.8 in patients with extrahepatic portal hypertension, and 23.6 +/- 6.5 in the control group; p < 0.007). These data showed a difference between the groups and suggest that nitric oxide, predominantly independent of cirrhosis, plays a primary role in the pathogenesis of portal hypertension.
Vida Shams; Tülay Erkan; Mustafa K Gümüstas; Fügen Cullu; Tufan Kutlu; Hafize Kaya; Seval Aydin; Güngör Tümay
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of tropical pediatrics     Volume:  49     ISSN:  0142-6338     ISO Abbreviation:  J. Trop. Pediatr.     Publication Date:  2003 Feb 
Date Detail:
Created Date:  2003-03-12     Completed Date:  2003-04-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8010948     Medline TA:  J Trop Pediatr     Country:  England    
Other Details:
Languages:  eng     Pagination:  33-6     Citation Subset:  IM    
Department of Pediatrics Gastroenterology, Cerrahpasa Medical Faculty of Istanbul University, Istanbul, Turkey.
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MeSH Terms
Analysis of Variance
Blood Pressure
Case-Control Studies
Fibrosis / blood,  complications
Hypertension, Portal / blood*,  complications,  etiology
Nitric Oxide / blood*
Reg. No./Substance:
10102-43-9/Nitric Oxide

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