| The role of nitric oxide in mediating pancreatic endocrine responses to insulin-induced hypoglycaemia in the conscious calf. | |
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MedLine Citation:
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PMID: 10564707 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The role of nitric oxide (NO) in mediating pancreatic endocrine responses to moderate hypoglycaemia has been investigated in conscious unrestrained calves. The synthesis of endogenous NO was inhibited by the administration of N-nitro-L-arginine methyl ester (L-NAME; 100 mg kg-1 I.A.), while sodium nitroprusside was infused continuously (2-4 microg min-1 kg-1 I.V.) to mimic the tonic production of NO. This effectively abolished the rise in plasma pancreatic polypeptide (PP) concentration during moderate hypoglycaemia (0.7 nmol kg-1 insulin I.V.) and significantly reduced the response to more intense hypoglycaemia (2.0 nmol kg-1 insulin I. V.). In contrast, the glucagon response was not significantly affected in either group, although consistently higher plasma glucagon values were obtained in response to the higher dose of insulin following the administration of L-NAME. It is concluded that, in the absence of L-NAME, production of NO contributes to the PP response, but not the glucagon response to hypoglycaemia in this species under physiological conditions. |
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Authors:
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C M Edwards; M A Ghatei; S R Bloom; A V Edwards |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Experimental physiology Volume: 84 ISSN: 0958-0670 ISO Abbreviation: Exp. Physiol. Publication Date: 1999 Nov |
Date Detail:
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Created Date: 2000-01-27 Completed Date: 2000-01-27 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 9002940 Medline TA: Exp Physiol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 1107-13 Citation Subset: IM |
Affiliation:
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ICSM Endocrine Unit, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Glucose / metabolism Blood Pressure / drug effects Cattle Glucagon / blood Heart Rate / drug effects Hypoglycemia / chemically induced* Insulin / pharmacology* NG-Nitroarginine Methyl Ester / pharmacology Nitric Oxide / metabolism* Nitroprusside / pharmacology Pancreas / metabolism* Pancreatic Polypeptide / blood |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 10102-43-9/Nitric Oxide; 11061-68-0/Insulin; 15078-28-1/Nitroprusside; 50903-99-6/NG-Nitroarginine Methyl Ester; 59763-91-6/Pancreatic Polypeptide; 9007-92-5/Glucagon |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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