Document Detail

The role of nitric oxide as an endogenous regulator of platelet and neutrophil activation within the pulmonary circulation of the rabbit.
MedLine Citation:
PMID:  1364849     Owner:  NLM     Status:  MEDLINE    
1. Intravenous (i.v.) administration of adenosine diphosphate (ADP), platelet activating factor (PAF) and thrombin induced a dose-related accumulation of 111indium-labelled platelets within the thoracic region of anaesthetized rabbits. 2. I.v. administration of the inhibitor of NO biosynthesis, L-NG-nitro arginine methyl ester (L-NAME; 10 mg kg-1) significantly potentiated the peak platelet accumulation induced by ADP, PAF and thrombin. Additionally L-NAME prolonged the disaggregation of platelets in comparison to D-NAME (10 mg kg-1). Such changes were reversible by the administration of L-arginine (900 mg kg-1). 3. I.v. administration of PAF induced a small accumulation of 111indium-labelled neutrophils within the pulmonary circulation which could be greatly potentiated by pretreatment of the animals with L-NAME. In contrast, thrombin administration did not cause significant accumulation of 11indium-labelled erythrocytes in the pulmonary circulation of anaesthetized rabbits. 4. Intracarotid (i.c.) administration of thrombin induced a marked accumulation of radiolabelled platelets within the cranial vasculature which was not potentiated by the prior administration of L-NAME (at either 10 mg kg-1 or 100 mg kg-1). 5. These results suggest that endogenous NO may regulate platelet and polymorphonuclear leukocyte activation within the pulmonary but not the cerebral circulation of rabbits.
G R May; P Crook; P K Moore; C P Page
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  British journal of pharmacology     Volume:  102     ISSN:  0007-1188     ISO Abbreviation:  Br. J. Pharmacol.     Publication Date:  1991 Mar 
Date Detail:
Created Date:  1995-01-05     Completed Date:  1995-01-05     Revised Date:  2010-09-07    
Medline Journal Info:
Nlm Unique ID:  7502536     Medline TA:  Br J Pharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  759-63     Citation Subset:  IM    
Department of Pharmacology, King's College, University of London.
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MeSH Terms
Adenosine Diphosphate / pharmacology
Arginine / analogs & derivatives,  pharmacology
Cerebrovascular Circulation
NG-Nitroarginine Methyl Ester
Neutrophils / physiology*
Nitric Oxide / physiology*
Platelet Activating Factor / pharmacology
Platelet Activation*
Pulmonary Circulation*
Reg. No./Substance:
0/Platelet Activating Factor; 10102-43-9/Nitric Oxide; 50903-99-6/NG-Nitroarginine Methyl Ester; 58-64-0/Adenosine Diphosphate; 74-79-3/Arginine

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