Document Detail


The role of nicotine and nicotinic mechanisms in neuropsychiatric disease.
MedLine Citation:
PMID:  1677596     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cigarette smoking, and by implication nicotine, may be involved as a negative or positive risk factor in some neuropsychiatric disorders and possibly as a treatment in others. Nicotine exposure may be a negative risk factor for the development of Parkinson's disease, but a positive risk factor for the development of tardive dyskinesia. For Alzheimer's disease and Tourette's syndrome, the role of nicotine exposure is equivocal, however, the role of nicotine as a possible therapeutic agent, alone or in combination, remains an intriguing question. For functional psychiatric disorders, the data are suggestive of a link between tobacco use and at least exacerbation of some disorders. While nicotine exposure is unlikely to be critical in the genesis of these disorders, it may complicate the pharmacological therapeutics and long-term prognosis. Further research is needed to examine the actual importance of tobacco use in behavioural disturbances. The relative importance of central nicotinic mechanisms in normal and disordered human cognition and movement is now beginning to be fully explored.
Authors:
P A Newhouse; J R Hughes
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  British journal of addiction     Volume:  86     ISSN:  0952-0481     ISO Abbreviation:  Br J Addict     Publication Date:  1991 May 
Date Detail:
Created Date:  1991-09-05     Completed Date:  1991-09-05     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8804404     Medline TA:  Br J Addict     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  521-6     Citation Subset:  IM    
Affiliation:
Department of Psychiatry, University of Vermont College of Medicine, Burlington 05401.
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MeSH Terms
Descriptor/Qualifier:
Brain / drug effects,  physiopathology
Delirium, Dementia, Amnestic, Cognitive Disorders / physiopathology*,  psychology
Humans
Neurotransmitter Agents / physiology
Nicotine / administration & dosage,  adverse effects*
Smoking / adverse effects*,  physiopathology,  psychology
Substance Withdrawal Syndrome / physiopathology,  psychology
Substance-Related Disorders / physiopathology*,  psychology
Grant Support
ID/Acronym/Agency:
DA-00109/DA/NIDA NIH HHS; HL-39220/HL/NHLBI NIH HHS; R29-46225//PHS HHS
Chemical
Reg. No./Substance:
0/Neurotransmitter Agents; 54-11-5/Nicotine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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