| The role of neutrophil collagenase in endotoxic acute lung injury. | |
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MedLine Citation:
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PMID: 15315179 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of this study was to determine the role of neutrophil collagenase in the pathogenesis of acute lung injury induced by endotoxin. 28 Sprague-Dawley were randomized into control group and LPS-enduced groups. Samples of left lung were obtained in 2 h (group L1), 6 h (group L2), 12 h (group L3) after intravenous LPS. Immunohistochemsitry was employed for detection of expression of neutrophil collagenase. Pathological scores, lung wet/dry weight ratio and the number of neutrophils were measured. The results showed that the concentration of neutrophil collagenase in LPS-enduced groups (group L1, L2, L3) were significantly higher than that of control group (P<0.01). Pathological scores, lung wet/dry weight ratio and the number of neutrophils in LPS-enduced groups (group L1, L2, L3) were also significantly higher than that of control group (P<0.01). Moreover, among group L1, L2 and L3, there were significant correlations in concentration of neutrophil collagenase and pathological scores, lung wet/dry weight ratio, the number of neutrophils (P<0.05). The present study showed that neutrophil collagenase play an important role in the pathogenesis and progress of endotoxic acute lung injury. |
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Authors:
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Tao Xu; Bangxiong Zeng; Xingwang Li |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban Volume: 24 ISSN: 1672-0733 ISO Abbreviation: J. Huazhong Univ. Sci. Technol. Med. Sci. Publication Date: 2004 |
Date Detail:
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Created Date: 2004-08-18 Completed Date: 2006-05-03 Revised Date: 2006-12-14 |
Medline Journal Info:
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Nlm Unique ID: 101169627 Medline TA: J Huazhong Univ Sci Technolog Med Sci Country: China |
Other Details:
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Languages: eng Pagination: 196-8 Citation Subset: IM |
Affiliation:
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Department of Anesthesiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Endotoxins Female Lung / pathology Male Matrix Metalloproteinase 8 / metabolism* Random Allocation Rats Rats, Sprague-Dawley Respiratory Distress Syndrome, Adult / chemically induced, enzymology*, etiology*, pathology |
| Chemical | |
Reg. No./Substance:
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0/Endotoxins; EC 3.4.24.34/Matrix Metalloproteinase 8 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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