Document Detail

A role for near infrared spectroscopy in the assessment of intermittent claudication.
MedLine Citation:
PMID:  11782696     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Near infrared spectroscopy (NIRS) can be used to monitor muscle oxyhemoglobin (HbO2), deoxyhemoglobin (Hb) and cytochrome oxidase (CytOx) oxidation. We evaluated the changes in NIRS in patients with intermittent claudication (IC) pre- and postexercise. Microalbuminuria is an index of endothelial dysfunction. Therefore, we also assessed whether the urinary excretion of albumin increased postexercise in patients with IC. METHODS: Each participant (14 patients with IC and 10 controls) underwent a treadmill test; NIRS was continuously recorded. The urinary albumin:creatinine ratio (ACR) and ankle: brachial systolic pressure index (ABPI) were measured pre- and postexercise. RESULTS: The ABPI in the claudicants dropped significantly (p<0.001) postexercise. The pre-exercise ACR did not differ between claudicants and controls but postexercise, the ACR increased significantly (p<0.001) in the claudicants. There was a significant (p<0.001) difference in the degree of HbO2 deoxygenation between claudicants and controls; the rate of deoxygenation was significantly higher in claudicants than in controls (-8.4 vs. -3.4 mol/L.min, p=0.024). The period of recovery of HbO2 postexercise was also significantly slower in claudicants (192 vs 68 sec, p=0.003). There was a significant correlation between the increase in the ACR and time of recovery of HbO2 levels postexercise (r=0.86, p<0.001, n=24). A similar pattern was seen with CytOx. CONCLUSIONS: NIRS may provide a simple, non-invasive assessment of the severity of IC. Furthermore, because the ACR is a marker of endothelial damage, it is possible that NIRS changes also reflect endothelial integrity. These applications of NIRS technique should be assessed in a larger study.
A M Seifalian; A Atwal; S White; D P Mikhailidis; D Baker; G Hamilton
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International angiology : a journal of the International Union of Angiology     Volume:  20     ISSN:  0392-9590     ISO Abbreviation:  Int Angiol     Publication Date:  2001 Dec 
Date Detail:
Created Date:  2002-01-09     Completed Date:  2002-10-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8402693     Medline TA:  Int Angiol     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  301-6     Citation Subset:  IM    
Vascular Unit, University Department of Surgery, Royal Free and University College Medical School, University College London and the Royal Free Hospital, London, UK.
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MeSH Terms
Aged, 80 and over
Creatinine / urine
Intermittent Claudication / diagnosis*,  urine
Middle Aged
Severity of Illness Index
Spectroscopy, Near-Infrared*
Reg. No./Substance:

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