| The role of the natural environment in the emergence of antibiotic resistance in Gram-negative bacteria. | |
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MedLine Citation:
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PMID: 23347633 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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During the past 10 years, multidrug-resistant Gram-negative Enterobacteriaceae have become a substantial challenge to infection control. It has been suggested by clinicians that the effectiveness of antibiotics is in such rapid decline that, depending on the pathogen concerned, their future utility can be measured in decades or even years. Unless the rise in antibiotic resistance can be reversed, we can expect to see a substantial rise in incurable infection and fatality in both developed and developing regions. Antibiotic resistance develops through complex interactions, with resistance arising by de-novo mutation under clinical antibiotic selection or frequently by acquisition of mobile genes that have evolved over time in bacteria in the environment. The reservoir of resistance genes in the environment is due to a mix of naturally occurring resistance and those present in animal and human waste and the selective effects of pollutants, which can co-select for mobile genetic elements carrying multiple resistant genes. Less attention has been given to how anthropogenic activity might be causing evolution of antibiotic resistance in the environment. Although the economics of the pharmaceutical industry continue to restrict investment in novel biomedical responses, action must be taken to avoid the conjunction of factors that promote evolution and spread of antibiotic resistance. |
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Authors:
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Elizabeth Mh Wellington; Alistair Ba Boxall; Paul Cross; Edward J Feil; William H Gaze; Peter M Hawkey; Ashley S Johnson-Rollings; Davey L Jones; Nicholas M Lee; Wilfred Otten; Christopher M Thomas; A Prysor Williams |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Lancet infectious diseases Volume: 13 ISSN: 1474-4457 ISO Abbreviation: Lancet Infect Dis Publication Date: 2013 Feb |
Date Detail:
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Created Date: 2013-01-25 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101130150 Medline TA: Lancet Infect Dis Country: United States |
Other Details:
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Languages: eng Pagination: 155-65 Citation Subset: IM |
Copyright Information:
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Copyright © 2013 Elsevier Ltd. All rights reserved. |
Affiliation:
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School of Life Sciences, University of Warwick, Coventry, UK. Electronic address: e.m.h.wellington@warwick.ac.uk. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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