Document Detail


The role of myostatin and the calcineurin-signalling pathway in regulating muscle mass in response to exercise training in the rainbow trout Oncorhynchus mykiss Walbaum.
MedLine Citation:
PMID:  15914652     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Rainbow trout Oncorhynchus mykiss Walbaum were exercised at 0.8 and 1.6 body lengths s(-1) for 18 h a day over a 30 day period. Exercise resulted in a 24-30% increase in the average cross-sectional area of fast muscle fibres relative to tank-rested controls. The concentrations of growth factors and transcription factors hypothesised to play a role in regulating exercise-induced muscle fibre hypertrophy were measured. Exercise training resulted in a minor increase in calcineurin localisation in the nucleus. However, nuclear factor of T-cells 2 (NFAT2) nuclear localisation did not follow a pattern that was consistent with NFAT2-mediated transcriptional activity and changes in calcineurin signaling. The active peptide of myostatin, a negative regulator of muscle growth in mammals, was downregulated in exercise groups relative to tank-rested controls, but only by 6-7%. It was concluded that myostatin and calcineurin signaling do not play a major role in regulating exercise-induced muscle hypertrophy in trout.
Authors:
C I Martin; I A Johnston
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of experimental biology     Volume:  208     ISSN:  0022-0949     ISO Abbreviation:  J. Exp. Biol.     Publication Date:  2005 Jun 
Date Detail:
Created Date:  2005-05-25     Completed Date:  2005-08-09     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0243705     Medline TA:  J Exp Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  2083-90     Citation Subset:  IM    
Affiliation:
Gatty Marine Laboratory, School of Biology, University of St Andrews, St Andrews, Scotland KY16 8LB, UK.
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MeSH Terms
Descriptor/Qualifier:
Animals
Calcineurin / metabolism,  physiology*
Gene Expression
Mice
Muscle Fibers, Fast-Twitch / physiology
Muscle, Skeletal / growth & development*,  metabolism
Myostatin
Oncorhynchus mykiss / metabolism,  physiology*
Physical Exertion / physiology*
Rats
Salmo salar
Signal Transduction / physiology*
Transforming Growth Factor beta / metabolism,  physiology*
Chemical
Reg. No./Substance:
0/Gdf8 protein, rat; 0/Mstn protein, mouse; 0/Myostatin; 0/Transforming Growth Factor beta; EC 3.1.3.16/Calcineurin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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