Document Detail

The role of multiple opioid receptors in the potentiation of reward by food restriction.
MedLine Citation:
PMID:  8205479     Owner:  NLM     Status:  MEDLINE    
Chronic food restriction and weight loss were previously shown to produce a naltrexone-reversible facilitation of perifornical lateral hypothalamic self-stimulation. In the present study, high affinity receptor-selective antagonists were used to determine the particular opioid receptor type(s) that mediates the facilitation of reward by food restriction. Separate groups of food-restricted and ad libitum fed rats were used to conduct i.c.v. dose-response studies with TCTAP (mu), norbinaltorphimine (kappa), and naltrindole (delta). The highest dose of naltrindole (50.0 nmol) raised self-stimulation threshold independently of feeding condition. This suggests that delta opioid activity is involved in self-stimulation under basal conditions and may explain previous findings that high systemic doses of naloxone or naltrexone reduce self-stimulation. The highest doses of TCTAP and norbinaltorphimine (5.0 and 50.0 nmol, respectively) reversed the lowering of self-stimulation threshold produced by food restriction while having no effect on thresholds of ad libitum fed rats. These results suggest that state-dependent mu and kappa opioid activity facilitate reward. Since food restriction is known to increase the rewarding effect of food and drugs of abuse, the opioid mechanism identified in the present study may mediate adaptive behavior and, under some circumstances, pathological behavior. The possible relation of state-dependent opioid activity to Anorexia Nervosa, binge eating, and the high comorbidity of eating disorders and substance abuse is discussed.
K D Carr; V Papadouka
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Brain research     Volume:  639     ISSN:  0006-8993     ISO Abbreviation:  Brain Res.     Publication Date:  1994 Mar 
Date Detail:
Created Date:  1994-07-13     Completed Date:  1994-07-13     Revised Date:  2014-03-25    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  253-60     Citation Subset:  IM    
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MeSH Terms
Behavior, Animal / drug effects
Brain / physiology
Conditioning, Operant / drug effects
Dose-Response Relationship, Drug
Food Deprivation / physiology*
Injections, Intraventricular
Naltrexone / analogs & derivatives,  pharmacology
Oligopeptides / pharmacology
Rats, Sprague-Dawley
Receptors, Opioid / antagonists & inhibitors,  drug effects,  physiology*
Receptors, Opioid, delta / antagonists & inhibitors,  physiology
Receptors, Opioid, kappa / antagonists & inhibitors,  physiology
Receptors, Opioid, mu / antagonists & inhibitors,  physiology
Self Stimulation
Grant Support
Reg. No./Substance:
0/1,2,3,4-tetrahydro-3-isoquinolinecarbonyl-cysteinyl-tyrosyl-tryptophyl-arginyl-threonyl-penicillamyl-threoninamide; 0/Oligopeptides; 0/Receptors, Opioid; 0/Receptors, Opioid, delta; 0/Receptors, Opioid, kappa; 0/Receptors, Opioid, mu; 105618-26-6/norbinaltorphimine; 111555-53-4/naltrindole; 5S6W795CQM/Naltrexone

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