Document Detail


The role of mitochondrial proteomic analysis in radiological accidents and terrorism.
MedLine Citation:
PMID:  22879026     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
In the wake of the 9/11 terrorist attacks and the recent Level 7 nuclear event at the Fukushima Daiichi plant, there has been heightened awareness of the possibility of radiological terrorism and accidents and the need for techniques to estimate radiation levels after such events. A number of approaches to monitoring radiation using biological markers have been published, including physical techniques, cytogenetic approaches, and direct, DNA-analysis approaches. Each approach has the potential to provide information that may be applied to the triage of an exposed population, but problems with development and application of devices or lengthy analyses limit their potential for widespread application. We present a post-irradiation observation with the potential for development into a rapid point-of-care device. Using simple mitochondrial proteomic analysis, we investigated irradiated and nonirradiated murine mitochondria and identified a protein mobility shift occurring at 2-3 Gy. We discuss the implications of this finding both in terms of possible mechanisms and potential applications in bio-radiation monitoring.
Authors:
David Maguire; Bingrong Zhang; Amy Zhang; Lurong Zhang; Paul Okunieff
Related Documents :
11542866 - On the development of biophysical models for space radiation risk assessment.
16728416 - Patient and staff radiation doses from early radiological examinations (1899-1902).
11541286 - Comparative diversification dynamics among palaeocontinents during the ordovician radia...
15695796 - A paired-image radiation transport model for skeletal dosimetry.
8703436 - Modelling for waste water treatment by rhodopseudomonas palustris y6 immobilized on fib...
25079396 - Automatic detection and resolution of measurement-unit conflicts in aggregated data.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Advances in experimental medicine and biology     Volume:  765     ISSN:  0065-2598     ISO Abbreviation:  Adv. Exp. Med. Biol.     Publication Date:  2013  
Date Detail:
Created Date:  2012-08-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0121103     Medline TA:  Adv Exp Med Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  139-45     Citation Subset:  IM    
Affiliation:
Department of Radiation Oncology, University of Florida, 103633, Gainesville, FL, 32610, USA, slh@ufl.edu.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Considering the vascular hypothesis of Alzheimer's disease: effect of copper associated amyloid on r...
Next Document:  Alteration of Plasma Galactose/N-acetylgalactosamine Level After Irradiation.