Document Detail

The role of mitochondrial haplogroups in non-arteritic anterior ischemic optic neuropathy.
MedLine Citation:
PMID:  18766989     Owner:  NLM     Status:  MEDLINE    
AIMS: To investigate a possible association between mitochondrial haplogroups and non-arteritic anterior ischemic optic neuropathy (NAION). METHODS: We compared the prevalence of various mitochondrial haplogroups in 24 NAION patients and 552 maternally unrelated ethnic controls. All patients and controls were Saudi Arabs. RESULTS: NAION patients had substantially more potentially pathologic mtDNA nucleotide changes (10/24) than Controls (0/159) and a significantly elevated mean relative mtDNA content (2.62 +/- 1.21) than controls (1.33 +/- 0.34; p < or = 0.001). There was no statistically significant difference between patients and controls for any of the mitochondrial haplogroups tested. CONCLUSIONS: Mitochondrial haplogroups do not appear to contribute to the pathogenesis of NAION in this cohort; however, mitochondrial abnormalities still seem likely to play a role.
Khaled K Abu-Amero; Jose M Larruga; Ana M González; Thomas M Bosley
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Ophthalmic genetics     Volume:  29     ISSN:  1744-5094     ISO Abbreviation:  Ophthalmic Genet.     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-09-03     Completed Date:  2008-09-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9436057     Medline TA:  Ophthalmic Genet     Country:  England    
Other Details:
Languages:  eng     Pagination:  111-6     Citation Subset:  IM    
Mitochondrial Research Laboratory, Department of Genetics, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia.
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MeSH Terms
DNA Mutational Analysis
DNA, Mitochondrial / analysis*
Haplotypes / genetics*
Middle Aged
Optic Neuropathy, Ischemic / genetics*
Polymerase Chain Reaction
Polymorphism, Restriction Fragment Length
Sequence Analysis, DNA
Reg. No./Substance:
0/DNA, Mitochondrial

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