| The role of mitochondrial haplogroups in non-arteritic anterior ischemic optic neuropathy. | |
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MedLine Citation:
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PMID: 18766989 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIMS: To investigate a possible association between mitochondrial haplogroups and non-arteritic anterior ischemic optic neuropathy (NAION). METHODS: We compared the prevalence of various mitochondrial haplogroups in 24 NAION patients and 552 maternally unrelated ethnic controls. All patients and controls were Saudi Arabs. RESULTS: NAION patients had substantially more potentially pathologic mtDNA nucleotide changes (10/24) than Controls (0/159) and a significantly elevated mean relative mtDNA content (2.62 +/- 1.21) than controls (1.33 +/- 0.34; p < or = 0.001). There was no statistically significant difference between patients and controls for any of the mitochondrial haplogroups tested. CONCLUSIONS: Mitochondrial haplogroups do not appear to contribute to the pathogenesis of NAION in this cohort; however, mitochondrial abnormalities still seem likely to play a role. |
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Authors:
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Khaled K Abu-Amero; Jose M Larruga; Ana M González; Thomas M Bosley |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Ophthalmic genetics Volume: 29 ISSN: 1744-5094 ISO Abbreviation: Ophthalmic Genet. Publication Date: 2008 Sep |
Date Detail:
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Created Date: 2008-09-03 Completed Date: 2008-09-25 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9436057 Medline TA: Ophthalmic Genet Country: England |
Other Details:
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Languages: eng Pagination: 111-6 Citation Subset: IM |
Affiliation:
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Mitochondrial Research Laboratory, Department of Genetics, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia. abuamero@gmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged DNA Mutational Analysis DNA, Mitochondrial / analysis* Female Haplotypes / genetics* Humans Male Middle Aged Optic Neuropathy, Ischemic / genetics* Polymerase Chain Reaction Polymorphism, Restriction Fragment Length Sequence Analysis, DNA |
| Chemical | |
Reg. No./Substance:
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0/DNA, Mitochondrial |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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