Document Detail


The role of microRNAs in B-cell development and function.
MedLine Citation:
PMID:  23314697     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
MicroRNA (miRNA)-mediated gene silencing at the translational level has led to novel discoveries for numerous biological processes. Recently, there has been increasing evidence to indicate that miRNAs are involved in normal immune functions and inflammation. In this review, we focus on recent advances that have elucidated the role of miRNAs in B-cell development, differentiation, apoptosis and function. While the regulatory mechanisms of miRNAs in controlling and maintaining B-cell fate remain largely uncharacterized, further studies on miRNAs and their targets will increase our understanding of B-cell development and function. Such studies may be able to provide new therapeutic strategies for treating autoimmune diseases.
Authors:
Jingyi Li; Ying Wan; Qing Ji; Yongfei Fang; Yuzhang Wu
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2013-01-14
Journal Detail:
Title:  Cellular & molecular immunology     Volume:  10     ISSN:  2042-0226     ISO Abbreviation:  Cell. Mol. Immunol.     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-03-04     Completed Date:  2013-06-18     Revised Date:  2014-08-19    
Medline Journal Info:
Nlm Unique ID:  101242872     Medline TA:  Cell Mol Immunol     Country:  China    
Other Details:
Languages:  eng     Pagination:  107-12     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Apoptosis / genetics,  immunology
B-Lymphocyte Subsets / cytology*,  immunology*,  metabolism
Cell Differentiation / genetics*,  immunology*
Drug Delivery Systems / methods
Humans
MicroRNAs / genetics,  physiology*
RNA, Messenger / metabolism
Chemical
Reg. No./Substance:
0/MicroRNAs; 0/RNA, Messenger
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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