Document Detail


The role of microRNAs in B-cell development and function.
MedLine Citation:
PMID:  23314697     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
MicroRNA (miRNA)-mediated gene silencing at the translational level has led to novel discoveries for numerous biological processes. Recently, there has been increasing evidence to indicate that miRNAs are involved in normal immune functions and inflammation. In this review, we focus on recent advances that have elucidated the role of miRNAs in B-cell development, differentiation, apoptosis and function. While the regulatory mechanisms of miRNAs in controlling and maintaining B-cell fate remain largely uncharacterized, further studies on miRNAs and their targets will increase our understanding of B-cell development and function. Such studies may be able to provide new therapeutic strategies for treating autoimmune diseases.Cellular & Molecular Immunology advance online publication, 14 January 2013; doi:10.1038/cmi.2012.62.
Authors:
Jingyi Li; Ying Wan; Qing Ji; Yongfei Fang; Yuzhang Wu
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-14
Journal Detail:
Title:  Cellular & molecular immunology     Volume:  -     ISSN:  2042-0226     ISO Abbreviation:  Cell. Mol. Immunol.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101242872     Medline TA:  Cell Mol Immunol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
1] Department of Rheumatology, Southwest Hospital, Third Military Medical University, Chongqing 400038, China [2] Institute of Immunology, PLA, Third Military Medical University, Chongqing 400038, China.
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