Document Detail


The role of miRNA in the direct and indirect effects of ionizing radiation.
MedLine Citation:
PMID:  21928045     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
This review focuses on a number of recent studies that have examined changes in microRNA (miRNA) expression profiles in response to ionizing radiation and other forms of oxidative stress. In both murine and human cells and tissues, a number of miRNAs display significant alterations in expression levels in response to both direct and indirect radiation exposure. In terms of direct irradiation, or exposure to agents that induce oxidative stress, miRNA array analyses indicate that a number of miRNAs are up- and down-regulated and, in particular, the let-7 family of miRNAs may well be critical in the cellular response to oxidative stress. In bystander cells that are not directly irradiated, but close to, or share media with directly irradiated cells or tissues, the miRNA expression profiles are also altered, but are somewhat distinct from the directly irradiated cells. Based on the results of these numerous studies, as well as our own data presented here, we conclude that miRNA regulation is a critical step in the cellular response to radiation and oxidative stress and that future studies should elucidate the mechanisms through which this altered regulation affects cell metabolism.
Authors:
Jennifer S Dickey; Franz J Zemp; Olga A Martin; Olga Kovalchuk
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-9-18
Journal Detail:
Title:  Radiation and environmental biophysics     Volume:  -     ISSN:  1432-2099     ISO Abbreviation:  -     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-9-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0415677     Medline TA:  Radiat Environ Biophys     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Laboratory of Biochemistry, Division of Therapeutic Proteins, CDER, FDA, 29 Lincoln Drive, Bldg 29A, Room 2B-24, Bethesda, MD, 20892, USA, Jennifer.dickey@fda.hhs.gov.
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