| The role of methylglyoxal-modified proteins in gastric ulcer healing. | |
| | |
MedLine Citation:
|
PMID: 22300087 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Methylglyoxal is a reactive dicarbonyl compound produced from cellular glycolytic intermediates that reacts nonenzymatically with proteins to form products such as argpyrimidine at arginine residues. Abnormal accumulation of methylglyoxal and methylglyoxalderived advanced glycation end products (AGEs) occurs under hyperglycemic conditions and has been implicated in endothelium dysfunction, arterial stiffening, and microvascular complications in diabetes. However, the role of methylglyoxal in the healing process of diabetic gastric ulcers has not been fully investigated. Recently, methylglyoxal modification of peroxiredoxin-VI was found to be associated with delayed healing of diabetic gastric ulcers. Thus, inhibition of methylglyoxal modification might have therapeutic potential for the treatment of such ulcers. In this review, we present what is currently known regarding the role of methylglyoxal in the healing of diabetic gastric ulcers. |
| | |
Authors:
|
T Takagi; Y Naito; T Oya-Ito; T Yoshikawa |
Related Documents
:
|
22028997 - Ramadan and diabetes: as-saum (the fasting). 16899927 - Polymorphonuclear leukocyte membrane fluidity and cytosolic ca2+ concentration in subje... 16969827 - A biodegradable copolymer for the slow release of growth hormone expedites scarring in ... 20566667 - The redox enzyme p66shc contributes to diabetes and ischemia-induced delay in cutaneous... 15181097 - Postprandial response of plasma ghrelin levels to various test meals in relation to foo... 20001897 - Does it make sense that diabetes is reciprocally associated with periodontal disease? |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Current medicinal chemistry Volume: 19 ISSN: 1875-533X ISO Abbreviation: Curr. Med. Chem. Publication Date: 2012 Jan |
Date Detail:
|
Created Date: 2012-02-03 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9440157 Medline TA: Curr Med Chem Country: Netherlands |
Other Details:
|
Languages: eng Pagination: 137-44 Citation Subset: IM |
Affiliation:
|
Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto 602-8566, Japan. ynaito@koto.kpu-m.ac.jp. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: MicroRNAs and Chronic Inflammation Contribution to Gastrointestinal Integrity.
Next Document: The Inhibition of Cell Proliferation Using Silencing of N-Cadherin Gene by siRNA Process in Human Me...