| The role of methylene blue in serotonin syndrome: a systematic review. | |
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MedLine Citation:
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PMID: 20484716 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: A recent series of case reports has demonstrated a significant, previously unrecognized drug interaction between serotonin reuptake inhibitors (SRIs) and methylene blue (MB). OBJECTIVE: The authors review the case reports and clinical audits relevant to this interaction and consider the diagnosis of serotonin syndrome in these cases. METHOD: Articles were obtained from a systematic search of MEDLINE and PsychInfo databases, and from the bibliographies of relevant articles. Studies were considered relevant if the patient received MB and developed an acute confusional state, neuropsychiatric complications, or autonomic instability. RESULTS: The review identified nine case reports and two retrospective reviews; 26 patients developed an acute confusional state after MB infusion; 24 of these patients were taking an SRI, and 1 was taking clomipramine. Serotonin syndrome was a possible diagnosis in all 25 of these patients. CONCLUSION: SRIs can interact with MB, causing a serious adverse reaction consistent with serotonin syndrome. |
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Authors:
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Bradley K W Ng; Andrew J D Cameron |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Psychosomatics Volume: 51 ISSN: 1545-7206 ISO Abbreviation: Psychosomatics Publication Date: 2010 May-Jun |
Date Detail:
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Created Date: 2010-05-20 Completed Date: 2010-09-30 Revised Date: 2012-04-24 |
Medline Journal Info:
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Nlm Unique ID: 0376506 Medline TA: Psychosomatics Country: United States |
Other Details:
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Languages: eng Pagination: 194-200 Citation Subset: IM |
Affiliation:
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correspondence and Aged Care Mental Health, Robina Hospital, Gold Coast Health Service District, Locked Bag 15, Robina, QLD 4226, Australia. bkwng@hotmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Antidepressive Agents, Tricyclic / administration & dosage, toxicity Clomipramine / administration & dosage, toxicity Drug Interactions Female Humans Infusions, Intravenous Male Methylene Blue / administration & dosage, diagnostic use, toxicity* Middle Aged Postoperative Complications / chemically induced, diagnosis Serotonin Syndrome / diagnosis, etiology* Serotonin Uptake Inhibitors / administration & dosage, toxicity* |
| Chemical | |
Reg. No./Substance:
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0/Antidepressive Agents, Tricyclic; 0/Serotonin Uptake Inhibitors; 303-49-1/Clomipramine; 61-73-4/Methylene Blue |
| Comments/Corrections | |
Comment In:
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Psychosomatics. 2010 Sep-Oct;51(5):448-9
[PMID:
20833947
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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