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The role of metamizol induction for the detection of perfusion reversibility on thallium-201 myocardial perfusion scintigraphy.
MedLine Citation:
PMID:  21063233     Owner:  NLM     Status:  In-Data-Review    
OBJECTIVE: Metamizol, probably with its vascular smooth muscle relaxant effect, enhances rest myocardial perfusion with the use of technetium-99m-methoxyisobutylisonitrile. We aimed to investigate whether metamizol induction is also able to increase the detectability of the ischemic/jeopardized myocardium during thallium-201 myocardial perfusion scintigraphy (MPS).
METHODS: Twenty patients who had partially reversible/irreversible perfusion defects on their routine stress-redistribution-reinjection thallium-201 MPS were enrolled and metamizol-induced thallium-201 MPS (111 MBq thallium-201 was injected 45 min after 1 g oral metamizol) was acquired (10 min, 1 and 3 h later). Routine MPS and metamizol-induced MPS images were interpreted on the model of 17 segments using a visual uptake score (VUS; 0=normal, 1=mild, 2=moderate, 3=significant decreases, 4=no uptake). Thallium-201 uptake ratios (mean counts in the region of the perfusion defect/mean counts in the region of the normal-perfused wall) were calculated for each MPS. Blood pressure was monitored at 15-min intervals. MPS were compared with coronary angiography results.
RESULTS: Visual uptake score and thallium-201 uptake ratio results indicated that in the first and third hour metamizol-induced thallium-201 uptake was significantly higher (P<0.001) than the redistribution/reinjection studies in 26 ischemic myocardial walls. Fourteen myocardial walls showed no thallium-201 uptake on either MPS and were considered as myocardial infarction. Statistically significant but asymptomatic decreases in blood pressure were observed. Coronary angiography results were in concordance with metamizol-induced MPS.
CONCLUSION: Metamizol increases the detectability of ischemic/viable myocardium during MPS with thallium-201 and could be used with MPS.
Tamer Aksoy; Eser Lay Ergün; Hakan Ergün
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Nuclear medicine communications     Volume:  32     ISSN:  1473-5628     ISO Abbreviation:  Nucl Med Commun     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2010-12-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8201017     Medline TA:  Nucl Med Commun     Country:  England    
Other Details:
Languages:  eng     Pagination:  129-36     Citation Subset:  IM    
aDepartment of Nuclear Medicine, Hacettepe University bDepartment of Medical Pharmacology, Ankara University, Ankara cDepartment of Nuclear Medicine, Faculty of Medicine, Afyon Kocatepe University, Afyonkarahisar, Turkey.
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